Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 13/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 13/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | OGT | O15294 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6719207 | 0.86 | SIGMAR1 (0.49) | SIGMAR1LMNAMAPTTDP1 | |
| SCHEMBL7787717 | 0.79 | HSD17B1 (0.38) | HSD17B1HSD17B2SIGMAR1LMNAMAPT | |
| SCHEMBL7622139 | 0.78 | HSD17B1 (0.43) | HSD17B1HSD17B2SIGMAR1NR1I2LMNA | |
| SCHEMBL6727836 | 0.78 | SIGMAR1 (0.47) | SIGMAR1LMNAMAPTTDP1 | |
| SCHEMBL6717067 | 0.77 | SIGMAR1 (0.41) | SIGMAR1 | |
| SCHEMBL6727771 | 0.75 | SIGMAR1 (0.44) | SIGMAR1 | |
| SCHEMBL7622243 | 0.74 | TSHR (0.38) | SIGMAR1LMNACYP3A4 | |
| SCHEMBL6716496 | 0.73 | SIGMAR1 (0.60) | SIGMAR1LMNAMAPTTDP1 | |
| SCHEMBL7615501 | 0.72 | SIGMAR1 (0.36) | SIGMAR1LMNACYP3A4 | |
| SCHEMBL7417688 | 0.71 | SIGMAR1 (0.64) | SIGMAR1LMNAMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251948-B1 | Tri-and tetra-substituted guanidines and their use as excitatory amino acid antagonists | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY AND THE UNIVERSITY OF OREGON | 2001-06-26 | — | — | US | claimed |
| US-5559154-A | Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists | OREGON STATE BOARD OF HIGHER EDUCATION | 1996-09-24 | — | — | US | claimed |