Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9261826 | 0.82 | CYP2C9 (0.51) | BLMLMNAHSD17B10TSHRNFKB1 | |
| SCHEMBL6512389 | 0.82 | GRM8 (0.45) | BLMKDM4ELMNATDP1PMP22 | |
| SCHEMBL5860807 | 0.81 | DPP4 (0.56) | KDM4ELMNAHIF1AMAPK1ADRA2A | |
| SCHEMBL939042 | 0.81 | DPP4 (0.56) | KDM4ELMNAHIF1AMAPK1ADRA2A | |
| SCHEMBL4073511 | 0.81 | DPP4 (0.56) | KDM4ELMNAHIF1AMAPK1ADRA2A | |
| SCHEMBL487425 | 0.81 | DPP4 (0.56) | KDM4ELMNAHIF1AMAPK1ADRA2A | |
| SCHEMBL8058962 | 0.81 | DPP4 (0.56) | KDM4ELMNAHIF1AMAPK1ADRA2A | |
| SCHEMBL939043 | 0.81 | DPP4 (0.56) | KDM4ELMNAHIF1AMAPK1ADRA2A | |
| SCHEMBL9257685 | 0.80 | LMNA (0.43) | BLMKDM4ELMNATDP1PMP22 | |
| SCHEMBL7631469 | 0.80 | ANPEP (0.52) | TPMTTDP1HSD17B10TSHRSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6444825-B1 | CHEMICAL INTERMEDIATE FOR TAXOL | AVENTIS PHARMA S.A. (FR) | 2002-09-03 | — | — | US | disclosed |
| US-6043375-A | Process for the preparation of an oxazolidinecarboxylic acid which is useful for preparing therapeutically active taxoids | RHONE-POULENC RORER S.A. (FR) | 2000-03-28 | — | — | US | disclosed |