Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 4/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SGK1 | O00141 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22928020 | 0.85 | CCR2 (0.47) | CCR2NLRP3ALDH1A1MEN1KMT2A | |
| SCHEMBL8227599 | 0.75 | CCR2 (0.46) | CCR2NLRP3ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL13485838 | 0.75 | CA2 (0.45) | CCR2NLRP3ALDH1A1MEN1KMT2A | |
| SCHEMBL24806202 | 0.74 | CCR2 (0.43) | CCR2NLRP3ALDH1A1MEN1KMT2A | |
| SCHEMBL29813636 | 0.71 | CCR2 (0.46) | CCR2NLRP3ALDH1A1MEN1KMT2A | |
| SCHEMBL29813806 | 0.71 | CCR2 (0.43) | CCR2NLRP3ALDH1A1MEN1KMT2A | |
| SCHEMBL8062374 | 0.70 | NLRP3 (0.50) | CCR2NLRP3ALDH1A1MEN1KMT2A | |
| SCHEMBL13956520 | 0.70 | CCR2 (0.43) | CCR2NLRP3ALDH1A1MEN1KMT2A | |
| SCHEMBL29059476 | 0.70 | ALDH1A1 (0.51) | CCR2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8063559 | 0.69 | NLRP3 (0.49) | CCR2NLRP3ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214087-A1 | COMBINATION TREATMENT WITH IL-1RA AND COMPOUNDS THAT INHIBIT IL-1 PROCESSING AND RELEASE | Pfizer Products Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019390-A1 | COMBINATION TREATMENT WITH IL-1RA AND DIARYL SULPHONYL UREA COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2001-03-22 | — | — | WO | disclosed |