Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | DHFR | P00374 | 2/20 | 0.38 |
| ▸ | DCPS | Q96C86 | 2/20 | 0.38 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7612960 | 0.88 | SGMS2 (0.46) | SMN1; SMN2LMNAMAPTHTTCYP1A2 | |
| SCHEMBL9528492 | 0.83 | MAPT (0.54) | SMN1; SMN2LMNAPOLBMAPTSTAT3 | |
| SCHEMBL7614912 | 0.80 | DRD2 (0.48) | SMN1; SMN2LMNAPOLBMAPTSTAT3 | |
| SCHEMBL7619113 | 0.77 | L3MBTL1 (0.54) | SMN1; SMN2LMNAPOLBMAPTSTAT3 | |
| SCHEMBL7616818 | 0.74 | CYP3A4 (0.37) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9528423 | 0.74 | MAPT (0.53) | SMN1; SMN2LMNAPOLBMAPTSTAT3 | |
| SCHEMBL4611131 | 0.71 | ALDH1A1 (0.46) | SMN1; SMN2LMNAPOLBMAPTHTT | |
| SCHEMBL9529218 | 0.69 | DRD2 (0.45) | MAPTPARP1KMT2AAR | |
| SCHEMBL24818523 | 0.69 | KDM4E (0.41) | POLBMAPTPARP1 | |
| SCHEMBL7610738 | 0.68 | CYP3A4 (0.44) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906288-B1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2002-11-06 | — | — | EP | claimed |
| US-6465505-B1 | SUCH AS 4-(2,6-DIMETHYLBENZYLAMINO OR BENZYLOXY)-2-METHYL BENZIMIDAZOLE; INHIBITING EXOGENOUS OR ENDOGENOUS STIMULATED GASTRIC ACID SECRETION; PREVENTION AND TREATMENT OF GASTRO-INTESTINAL INFLAMMATORY DISEASES | ASTRAZENECA AB (SE) | 2002-10-15 | — | — | US | claimed |
| EP-0906288-A1 | NEW COMPOUNDS | Astra Aktiebolag (SE) | 1999-04-07 | — | — | EP | claimed |
| WO-1997047603-A1 | NEW COMPOUNDS | ASTRA AKTIEBOLAG (SE) | 1997-12-18 | — | — | WO | claimed |
| EP-0906288-B1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2002-11-06 | — | — | EP | disclosed |
| US-6465505-B1 | SUCH AS 4-(2,6-DIMETHYLBENZYLAMINO OR BENZYLOXY)-2-METHYL BENZIMIDAZOLE; INHIBITING EXOGENOUS OR ENDOGENOUS STIMULATED GASTRIC ACID SECRETION; PREVENTION AND TREATMENT OF GASTRO-INTESTINAL INFLAMMATORY DISEASES | ASTRAZENECA AB (SE) | 2002-10-15 | — | — | US | disclosed |
| EP-0906288-A1 | NEW COMPOUNDS | Astra Aktiebolag (SE) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997047603-A1 | NEW COMPOUNDS | ASTRA AKTIEBOLAG (SE) | 1997-12-18 | — | — | WO | disclosed |