Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TK2 | O00142 | 8/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | RNASE1 | P07998 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8172947 | 0.91 | TK1 (0.33) | TK1HPGDTK2 | |
| SCHEMBL261290 | 0.85 | TK1 (0.33) | TK1HPGDTK2RNASE1 | |
| SCHEMBL7156110 | 0.77 | TK1 (0.34) | TK1HPGD | |
| SCHEMBL313036 | 0.76 | TK1 (0.32) | TK1HPGDTK2 | |
| SCHEMBL7247157 | 0.76 | TK1 (0.32) | TK1HPGDTK2 | |
| SCHEMBL1738254 | 0.76 | TK1 (0.31) | TK1TK2 | |
| SCHEMBL8171836 | 0.76 | TK1 (0.33) | TK1 | |
| SCHEMBL9396549 | 0.74 | RNASE1 (0.39) | TK1TK2RNASE1 | |
| SCHEMBL7065023 | 0.72 | TK1 (0.33) | TK1HPGDTK2 | |
| SCHEMBL3696551 | 0.70 | RNASE1 (0.36) | TK1HPGDTK2RNASE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6448080-B1 | CONTACTING CELLS OR TISSUES IN VITRO WITH THE ANTISENSE OLIGONUCLEOTIDE OF THE INVENTION SO THAT EXPRESSION OF HUMAN WRN IS INHIBITED. | ISIS PHARMACEUTICALS, INC. | 2002-09-10 | — | — | US | disclosed |
| US-6440739-B1 | POLYPEPTIDES; ANTICANCER AGENT; WOUND HEALING AGENTS | ISIS PHARMACEUTICALS, INC. | 2002-08-27 | — | — | US | disclosed |
| US-6440737-B1 | POLYPEPTIDES | ISIS PHARMACEUTICALS, INC. | 2002-08-27 | — | — | US | disclosed |
| US-5985663-A | AN ANTISENSE COMPOUND 8 TO 30 NUCLEOBASES IN LENGTH TARGETED TO A 5' UNTRANSLATED REGION OR 3' UNTRANSLATED REGION OF A NUCLEIC ACID ENCODING HUMAN INTERLEUKIN-15 | ISIS PHARMACEUTICALS INC. (US) | 1999-11-16 | — | — | US | disclosed |