Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 2/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6302398 | 0.93 | NPC1 (0.55) | NPC1RAB9ANR1H4MEN1EPHX2 | |
| SCHEMBL6296069 | 0.92 | NPC1 (0.60) | NPC1RAB9ANR1H4MEN1EPHX2 | |
| SCHEMBL6302829 | 0.90 | NPC1 (0.60) | NPC1RAB9ANR1H4MEN1EPHX2 | |
| SCHEMBL27214488 | 0.87 | L3MBTL1 (0.56) | RAB9AMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL6302831 | 0.85 | NPC1 (0.56) | NPC1RAB9ANR1H4MEN1EPHX2 | |
| SCHEMBL13175754 | 0.85 | PDE4A (0.63) | NPC1RAB9ANR1H4MEN1EPHX2 | |
| SCHEMBL30829109 | 0.83 | NPC1 (0.62) | NPC1RAB9ANR1H4MEN1EPHX2 | |
| SCHEMBL9416606 | 0.81 | NPC1 (0.82) | NPC1RAB9ANR1H4MEN1EPHX2 | |
| SCHEMBL11761142 | 0.81 | NPC1 (0.82) | NPC1RAB9ANR1H4MEN1EPHX2 | |
| SCHEMBL6239186 | 0.81 | NPC1 (0.61) | NPC1RAB9ANR1H4MEN1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020193377-A1 | Quinazolines as MMP-13 inhibitors | ANDRIANJARA CHARLES (FR) | 2002-12-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020193377-A1 | Quinazolines as MMP-13 inhibitors | MMP13, MMP9, MMP3 | NPC1 3752/4885RAB9A 1888/4885NR1H4 2332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.