Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 4/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11095419 | 1.00 | BACE1 (0.47) | BACE1HTR2ASLC6A2SLC6A4DRD2 | |
| SCHEMBL29387315 | 1.00 | BACE1 (0.47) | BACE1HTR2ASLC6A2SLC6A4DRD2 | |
| Hydrochloric Acid SCHEMBL25279576 | 0.98 | BACE1 (0.46) | BACE1HTR2ASLC6A2SLC6A4DRD2 | |
| SCHEMBL210677 | 0.91 | BACE1 (0.45) | BACE1HTR2ASLC6A2SLC6A4DRD2 | |
| SCHEMBL29384112 | 0.91 | BACE1 (0.45) | BACE1HTR2ASLC6A2SLC6A4DRD2 | |
| SCHEMBL30277974 | 0.89 | HTR2A (0.46) | BACE1HTR2ASLC6A2SLC6A4DRD2 | |
| Iodide SCHEMBL9047078 | 0.89 | BACE1 (0.44) | BACE1HTR2ASLC6A2SLC6A4DRD2 | |
| Hydrochloric Acid SCHEMBL6543309 | 0.89 | BACE1 (0.44) | BACE1HTR2ASLC6A2SLC6A4DRD2 | |
| Hydrochloric Acid SCHEMBL8063249 | 0.89 | BACE1 (0.44) | BACE1HTR2ASLC6A2SLC6A4DRD2 | |
| SCHEMBL1822909 | 0.84 | OPRM1 (0.42) | BACE1HTR2ASLC6A2SLC6A4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023164680-A1 | 6-OXODECAHYDROPYRROLO[1,2-A][1,5]DIAZOCINE AND 6-OXODECAHYDRO-4H-PYRROLO[2,1-D][1,5]THIAZOCINE DERIVATIVES AS STAT3 AND STAT6 MODULATORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY CONDITIONS | RECLUDIX PHARMA, INC. (US) | 2023-08-31 | — | — | WO | claimed |
| WO-2023133336-A1 | STAT MODULATORS AND USES THEREOF | RECLUDIX PHARMA, INC. (US) | 2023-07-13 | — | — | WO | claimed |
| WO-2023164680-A1 | 6-OXODECAHYDROPYRROLO[1,2-A][1,5]DIAZOCINE AND 6-OXODECAHYDRO-4H-PYRROLO[2,1-D][1,5]THIAZOCINE DERIVATIVES AS STAT3 AND STAT6 MODULATORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY CONDITIONS | RECLUDIX PHARMA, INC. (US) | 2023-08-31 | — | — | WO | disclosed |
| US-8138342-B2 | 11β-hydroxysteroid dehydrogenase type 1 active spiro compounds | High Point Pharmacueticals, LLC (US) | 2012-03-20 | — | — | US | disclosed |
| US-8138342-B2 | 11β-hydroxysteroid dehydrogenase type 1 active spiro compounds | High Point Pharmacueticals, LLC (US) | 2012-03-20 | — | — | US | disclosed |
| US-20090105289-A1 | 11beta-hydroxysteroid dehydrogenase type 1 active spiro compounds | NOVO NORDISK A/S (DK) | 2009-04-23 | — | — | US | disclosed |
| US-20090105289-A1 | 11beta-hydroxysteroid dehydrogenase type 1 active spiro compounds | NOVO NORDISK A/S (DK) | 2009-04-23 | — | — | US | disclosed |
| CN-1047386-C | Novel spiro [indole-pyrrolidine]derivatives as melatoninergic agonists, method for preparing same and use thereof as drug | CEMAF (FR) | 1999-12-15 | — | — | CN | disclosed |
| US-5763471-A | TREATS PSYCHIATARIC AND BRAIN DISORDERS | CEMAF (FR) | 1998-06-09 | — | — | US | disclosed |
| CN-1148855-A | Novel spiro [indole-pyrrolidine]derivatives as melatoninergic agonists, method for preparing same and use thereof as drug | CEMAF (FR) | 1997-04-30 | — | — | CN | disclosed |
| EP-0754183-A1 | NOVEL SPIRO[INDOLE-PYRROLIDINE] DERIVATIVES AS MELATONINERGIC AGONISTS, METHOD FOR PREPARING SAME AND USE THEREOF AS A DRUG | CEMAF (FR) | 1997-01-22 | — | — | EP | disclosed |
| WO-1995027712-A1 | NOVEL SPIRO[INDOLE-PYRROLIDINE] DERIVATIVES AS MELATONINERGIC AGONISTS, METHOD FOR PREPARING SAME AND USE THEREOF AS A DRUG | CEMAF (FR) | 1995-10-19 | — | — | WO | disclosed |
| US-4379932-A | Process for preparing spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1983-04-12 | — | — | US | disclosed |
| US-4379933-A | Process for preparing spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1983-04-12 | — | — | US | disclosed |
| US-4345081-A | Spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1982-08-17 | — | — | US | disclosed |
| US-4209625-A | Spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1980-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105289-A1 | 11beta-hydroxysteroid dehydrogenase type 1 active spiro compounds | HSD11B1, HSD3B1, HSD17B1 | BACE1 557/4885HTR2A 2457/4885SLC6A2 3013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.