Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | ALPI | P09923 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.46 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.45 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL8558897 | 0.88 | LMNA (0.50) | SIGMAR1LMNAGAASMN1; SMN2KMT2A | |
| Bicarbonate SCHEMBL8554569 | 0.88 | GAA (0.50) | SIGMAR1LMNAGAASMN1; SMN2KMT2A | |
| Bicarbonate SCHEMBL7620879 | 0.87 | SIGMAR1 (0.60) | SIGMAR1LMNAMAPTKMT2AMEN1 | |
| Bicarbonate SCHEMBL7615737 | 0.87 | SIGMAR1 (0.60) | SIGMAR1LMNAMAPTKMT2AMEN1 | |
| Bicarbonate SCHEMBL7615566 | 0.86 | SIGMAR1 (0.56) | SIGMAR1LMNATRPV1MAPTKMT2A | |
| Bicarbonate SCHEMBL7615137 | 0.86 | SIGMAR1 (0.58) | SIGMAR1LMNAMAPTKMT2AMEN1 | |
| Bicarbonate SCHEMBL7620040 | 0.85 | SIGMAR1 (0.55) | SIGMAR1LMNATRPV1MAPTKMT2A | |
| Bicarbonate SCHEMBL4428121 | 0.85 | GAA (0.66) | SIGMAR1LMNAGAASMN1; SMN2MAPT | |
| Bicarbonate SCHEMBL4432364 | 0.85 | MEN1 (0.57) | SIGMAR1LMNAGAASMN1; SMN2KMT2A | |
| Bicarbonate SCHEMBL7624111 | 0.84 | SIGMAR1 (0.65) | SIGMAR1LMNAKMT2AHPGDP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0596298-B1 | 5-Spirosubstituted 1-H-3-aryl-pyrrolidin-2,4-dione derivatives as herbicides, insecticides and acaricides | BAYER AG (DE) | 2002-01-09 | — | — | EP | disclosed |
| EP-0596298-A2 | 5-Spirosubstituted 1-H-3-aryl-pyrrolidin-2,4-dione derivatives as herbicides, insecticides and acaricides | BAYER AG (DE) | 1994-05-11 | — | — | EP | disclosed |