Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 8/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.44 |
| ▸ | DRD2 | P14416 | 7/20 | 0.44 |
| ▸ | HTR6 | P50406 | 7/20 | 0.44 |
| ▸ | HTR1A | P08908 | 6/20 | 0.44 |
| ▸ | HTR2A | P28223 | 6/20 | 0.44 |
| ▸ | HTR7 | P34969 | 4/20 | 0.44 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.37 |
| ▸ | DRD1 | P21728 | 4/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.37 |
| ▸ | DRD3 | P35462 | 4/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1110825 | 0.85 | DRD2 (0.34) | HRH1SLC6A4DRD2HTR6HTR1A | |
| SCHEMBL19656192 | 0.83 | CYP1A2 (0.35) | HRH1SLC6A4DRD2HTR6HTR1A | |
| SCHEMBL7708382 | 0.82 | ALDH1A1 (0.39) | HTR1ALMNAKDM4ECYP2D6ALDH1A1 | |
| SCHEMBL285328 | 0.82 | HTR1A (0.33) | HRH1SLC6A4DRD2HTR6HTR1A | |
| SCHEMBL591245 | 0.81 | CDC25A (0.40) | LMNAKDM4ECYP2D6ALDH1A1CNR1 | |
| SCHEMBL590886 | 0.81 | CDC25A (0.40) | LMNAKDM4ECYP2D6ALDH1A1CNR1 | |
| SCHEMBL344853 | 0.81 | CDC25A (0.40) | LMNAKDM4ECYP2D6ALDH1A1CNR1 | |
| SCHEMBL285430 | 0.80 | CHRM2 (0.31) | HRH1SLC6A4DRD2HTR1AHTR2A | |
| SCHEMBL284859 | 0.78 | TDP1 (0.43) | HRH1SLC6A4DRD2HTR6HTR1A | |
| SCHEMBL3730203 | 0.77 | GPR84 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002102783-A1 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2002-12-27 | — | — | WO | disclosed |