Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 7/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.43 |
| ▸ | CBR1 | P16152 | 2/20 | 0.43 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17942940 | 0.99 | AKR1B10 (0.43) | AKR1B10AKR1B1ALDH1A1KDM4EMAPT | |
| SCHEMBL15299580 | 0.97 | AKR1B10 (0.44) | AKR1B10AKR1B1ALDH1A1KDM4EMAPT | |
| SCHEMBL30423318 | 0.87 | AKR1B10 (0.43) | AKR1B10AKR1B1ALDH1A1KDM4EMAPT | |
| SCHEMBL25168020 | 0.87 | AKR1B10 (0.43) | AKR1B10AKR1B1ALDH1A1KDM4EMAPT | |
| SCHEMBL25167999 | 0.87 | AKR1B10 (0.43) | AKR1B10AKR1B1ALDH1A1KDM4EMAPT | |
| SCHEMBL25167167 | 0.87 | NAAA (0.44) | AKR1B10AKR1B1ALDH1A1KDM4EMAPT | |
| SCHEMBL30422928 | 0.87 | AKR1B10 (0.43) | AKR1B10AKR1B1ALDH1A1KDM4EMAPT | |
| SCHEMBL25167885 | 0.85 | AKR1B10 (0.42) | AKR1B10AKR1B1ALDH1A1KDM4EMAPT | |
| SCHEMBL25166772 | 0.84 | NAAA (0.42) | AKR1B10AKR1B1ALDH1A1KDM4EMAPT | |
| SCHEMBL30422923 | 0.84 | NAAA (0.42) | AKR1B10AKR1B1ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9284541-B2 | Methods and compositions for protein labeling using lipoic acid ligases | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2016-03-15 | — | — | US | disclosed |
| US-20150125904-A1 | PROBE INCORPORATION MEDIATED BY ENZYMES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-05-07 | — | — | US | disclosed |
| US-20150125904-A1 | PROBE INCORPORATION MEDIATED BY ENZYMES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-05-07 | — | — | US | disclosed |
| US-8871456-B2 | Probe incorporation mediated by enzymes | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2014-10-28 | — | — | US | disclosed |
| US-8871456-B2 | Probe incorporation mediated by enzymes | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2014-10-28 | — | — | US | disclosed |
| WO-2013052851-A1 | METHODS AND COMPOSITIONS FOR POLYPEPTIDE AND PROTEIN LABELING USING LIPOIC ACID LIGASES SPECIFIC TO RESORUFIN | MASSACHUSETTS INISTITUTE OF TECHNOLOGY (US) | 2013-04-11 | — | — | WO | disclosed |
| US-20120214201-A1 | PROBE INCORPORATION MEDIATED BY ENZYMES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-08-23 | — | — | US | disclosed |
| US-20120214201-A1 | PROBE INCORPORATION MEDIATED BY ENZYMES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-08-23 | — | — | US | disclosed |
| US-20120129159-A1 | METHODS AND COMPOSITIONS FOR PROTEIN LABELING USING LIPOIC ACID LIGASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-05-24 | — | — | US | disclosed |
| US-20120129159-A1 | METHODS AND COMPOSITIONS FOR PROTEIN LABELING USING LIPOIC ACID LIGASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-05-24 | — | — | US | disclosed |
| US-8137925-B2 | Methods and compositions for protein labeling using lipoic acid ligases | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-03-20 | — | — | US | disclosed |
| US-8137925-B2 | Methods and compositions for protein labeling using lipoic acid ligases | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129159-A1 | METHODS AND COMPOSITIONS FOR PROTEIN LABELING USING LIPOIC ACID LIGASES | LARS1, ACSL5, RARS1 | AKR1B10 3160/4885AKR1B1 3012/4885ALDH1A1 1936/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.