Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602995 | 0.77 | ALDH1A1 (0.49) | OPRM1SIGMAR1ALDH1A1CYP2D6TSHR | |
| SCHEMBL7815165 | 0.74 | ALDH1A1 (0.45) | OPRM1SIGMAR1ALDH1A1CYP2D6LMNA | |
| SCHEMBL6603001 | 0.73 | OPRM1 (0.47) | OPRM1SIGMAR1ALDH1A1CYP2D6TSHR | |
| SCHEMBL7815162 | 0.72 | CYP2D6 (0.47) | OPRM1SIGMAR1ALDH1A1CYP2D6TSHR | |
| SCHEMBL7625846 | 0.70 | OPRM1 (0.46) | OPRM1SIGMAR1ALDH1A1CYP2D6TSHR | |
| SCHEMBL7618708 | 0.69 | ALDH1A1 (0.50) | OPRM1SIGMAR1ALDH1A1CYP2D6TSHR | |
| SCHEMBL7815159 | 0.69 | ALDH1A1 (0.46) | OPRM1SIGMAR1ALDH1A1CYP2D6TSHR | |
| SCHEMBL7621104 | 0.69 | OPRM1 (0.48) | OPRM1SIGMAR1ALDH1A1CYP2D6 | |
| SCHEMBL7623544 | 0.66 | OPRM1 (0.49) | OPRM1SIGMAR1CYP2D6KMT2A | |
| SCHEMBL5538391 | 0.66 | SIGMAR1 (0.55) | OPRM1SIGMAR1ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6444677-B2 | TREATMENT OF INFLAMMATION, CARDIOVASCULAR DISEASE, PAIN, ETC. | PFIZER INC. | 2002-09-03 | — | — | US | disclosed |
| US-20010046993-A1 | 5-memberd heteroaryl substituted 1,4-dihydropyridine compounds as bradykinin antagonists | IKEDA TAKAFUMI (JP) | 2001-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010046993-A1 | 5-memberd heteroaryl substituted 1,4-dihydropyridine compounds as bradykinin antagonists | BDKRB1, BDKRB2, CNR2 | OPRM1 42/4885SIGMAR1 127/4885ALDH1A1 2557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.