Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.59 |
| ▸ | NT5E | P21589 | 6/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7627041 | 1.00 | ADORA3 (0.60) | ADORA3ADORA1ADORA2ANT5EADORA2B | |
| SCHEMBL8820534 | 0.92 | ADORA1 (0.70) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL8820548 | 0.92 | ADORA1 (0.70) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL8820284 | 0.84 | ALDH1A1 (0.55) | ADORA3ADORA1ADORA2ANT5E | |
| SCHEMBL8819342 | 0.84 | ALDH1A1 (0.55) | ADORA3ADORA1ADORA2ANT5E | |
| SCHEMBL8820255 | 0.83 | ADORA1 (0.73) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL8820273 | 0.83 | ADORA1 (0.73) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL5353431 | 0.81 | ADORA3 (0.67) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL8820021 | 0.80 | ADORA1 (0.63) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL8820039 | 0.80 | ADORA1 (0.63) | ADORA3ADORA1ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455510-B1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2002-09-24 | — | — | US | claimed |
| US-5589467-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | NOVO NORDISK A/S (DK) | 1996-12-31 | — | — | US | claimed |
| WO-1997033590-A1 | A METHOD OF TREATING DISORDERS RELATED TO CYTOKINES IN MAMMALS | NOVO NORDISK A/S (DK) | 1997-09-18 | — | — | WO | disclosed |
| WO-1997033591-A1 | A METHOD OF TREATING DISORDERS RELATED TO CYTOKINES IN MAMMALS | NOVO NORDISK A/S (DK) | 1997-09-18 | — | — | WO | disclosed |
| US-5589467-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | NOVO NORDISK A/S (DK) | 1996-12-31 | — | — | US | disclosed |