Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | CACNA1G | O43497 | 5/20 | 0.51 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6605017 | 0.91 | DRD4 (0.54) | DRD4CACNA1GDPP7MEN1TSHR | |
| SCHEMBL7625330 | 0.77 | ACHE (0.50) | DRD4CACNA1GMEN1TSHRKMT2A | |
| SCHEMBL6603960 | 0.77 | KDM4E (0.50) | CACNA1GSIGMAR1 | |
| SCHEMBL7631442 | 0.77 | NPFFR1 (0.52) | CYP2D6SIGMAR1 | |
| SCHEMBL2988825 | 0.75 | MEN1 (0.55) | DRD4CACNA1GDPP7MEN1TSHR | |
| SCHEMBL17469031 | 0.75 | ACHE (0.70) | DRD4 | |
| SCHEMBL9182416 | 0.75 | OPRM1 (0.43) | DRD4CYP2D6SIGMAR1 | |
| SCHEMBL16795160 | 0.74 | DRD4 (0.54) | DRD4CACNA1GDPP7MEN1TSHR | |
| SCHEMBL3937184 | 0.74 | NPFFR1 (0.66) | DRD4CACNA1GCYP2D6MEN1KMT2A | |
| SCHEMBL23070812 | 0.74 | NPFFR1 (0.60) | MEN1KMT2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6444677-B2 | TREATMENT OF INFLAMMATION, CARDIOVASCULAR DISEASE, PAIN, ETC. | PFIZER INC. | 2002-09-03 | — | — | US | disclosed |
| US-20010046993-A1 | 5-memberd heteroaryl substituted 1,4-dihydropyridine compounds as bradykinin antagonists | IKEDA TAKAFUMI (JP) | 2001-11-29 | — | — | US | disclosed |
| EP-1106614-A1 | 5-Membered heteroaryl substituted 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER INC. (US) | 2001-06-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010046993-A1 | 5-memberd heteroaryl substituted 1,4-dihydropyridine compounds as bradykinin antagonists | BDKRB1, BDKRB2, CNR2 | DRD4 998/4885CACNA1G 291/4885DPP7 916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.