Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7628560 | 1.00 | MTNR1A (0.46) | MTNR1AMTNR1BNAMPTALDH1A1CHRM2 | |
| SCHEMBL7618605 | 0.79 | HTT (0.49) | ALDH1A1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL7620196 | 0.76 | PDPK1 (0.44) | CHRM2CHRM1CHRM3TSHRSMN1; SMN2 | |
| SCHEMBL7620191 | 0.76 | PDPK1 (0.44) | CHRM2CHRM1CHRM3TSHRSMN1; SMN2 | |
| SCHEMBL7620201 | 0.76 | PDPK1 (0.44) | CHRM2CHRM1CHRM3TSHRSMN1; SMN2 | |
| SCHEMBL7617561 | 0.72 | CHRNA7 (0.45) | CHRM2CHRM1CHRM3TSHRSMN1; SMN2 | |
| SCHEMBL7617553 | 0.72 | CHRNA7 (0.45) | CHRM2CHRM1CHRM3TSHRSMN1; SMN2 | |
| SCHEMBL7617549 | 0.72 | CHRNA7 (0.45) | CHRM2CHRM1CHRM3TSHRSMN1; SMN2 | |
| SCHEMBL7626235 | 0.72 | CHRNA7 (0.45) | CHRM2CHRM1CHRM3TSHRSMN1; SMN2 | |
| SCHEMBL9494140 | 0.71 | SIGMAR1 (0.51) | ALDH1A1SMN1; SMN2OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436954-B1 | BENZO(B)QUINOLIZIDINE AND BENZO(F)INDOLIZIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF ALZHEIMER'S DISEASE, SENILE DEMENTIA OR OTHER CONDITIONS CHARACTERIZED BY MEMORY LOSS; PYRROLO(1,2-B)ISOQUINOLINES, BENZO(B)QUINOLIZINES | AMERICAN BIOGENETIC SCIENCES, INC. | 2002-08-20 | — | — | US | disclosed |