Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CBFB | Q13951 | 1/20 | 0.37 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7638791 | 0.85 | KMT2A (0.47) | ALDH1A1KMT2AMEN1MAPTMAPK1 | |
| SCHEMBL7636534 | 0.80 | ALDH1A1 (0.48) | ALDH1A1KMT2AMEN1GAALMNA | |
| SCHEMBL7630261 | 0.79 | KMT2A (0.46) | ALDH1A1KMT2AMEN1GAALMNA | |
| SCHEMBL7630166 | 0.77 | ALDH1A1 (0.42) | ALDH1A1KMT2AMEN1GAALMNA | |
| SCHEMBL8163013 | 0.72 | GFER (0.46) | ALDH1A1KMT2AMEN1GAALMNA | |
| SCHEMBL8163011 | 0.72 | GFER (0.43) | ALDH1A1KMT2AMEN1GAALMNA | |
| SCHEMBL7931629 | 0.69 | ALDH1A1 (0.53) | ALDH1A1KMT2AMEN1GAALMNA | |
| SCHEMBL7632391 | 0.68 | KMT2A (0.51) | ALDH1A1KMT2AMEN1GAALMNA | |
| SCHEMBL9665141 | 0.67 | MAPK1 (0.64) | ALDH1A1KMT2AHPGDKDM4EPOLB | |
| SCHEMBL1323737 | 0.66 | GFER (0.45) | ALDH1A1KMT2AMEN1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6459001-B1 | Tricyclic compounds, their preparation process and the intermediates of this process, their use as medicaments and the pharmaceutical compositions containing them | AVENTIS PHARMA S.A. (FR) | 2002-10-01 | — | — | US | disclosed |
| EP-0888292-B1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY SPECIFIC FOR INTEGRINS, PARTICULARLY ALPHAvBETA3 INTEGRINS, METHOD FOR PREPARING SAME, INTERMEDIATES THEREFOR, USE OF SAID COMPOUNDS AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2001-10-31 | — | — | EP | disclosed |
| US-6268520-B1 | USED FORPREPARATION OF OPTICALLY ACTIVE OR RACEMIC COLCHICINE AND THIOCOLCHICINE DERIVATIVES | HOECHST MARION ROUSSEL (FR) | 2001-07-31 | — | — | US | disclosed |
| US-6221907-B1 | Tricyclic compounds having activity specific for integrins, particularly alphanubeta3 integrins, method for preparing same, intermediates therefor, use of said compounds as drugs, and pharmaceutical compositions containing same | HOECHST MARION ROUSSEL (FR) | 2001-04-24 | — | — | US | disclosed |
| EP-0729933-B1 | Tricyclic derivatives, their preparation, their use in the preparation of optically active or racemic colchicine, thiocolchicine and analogues or derivatives, and intermediates | HOECHST MARION ROUSSEL INC (FR) | 2000-01-26 | — | — | EP | disclosed |
| EP-0888292-A1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY SPECIFIC FOR INTEGRINS, PARTICULARLY $g(a)v$g(b)3 INTEGRINS, METHOD FOR PREPARING SAME, INTERMEDIATES THEREFOR, USE OF SAID COMPOUNDS AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | HOECHST MARION ROUSSEL (FR) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997034865-A1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY SPECIFIC FOR INTEGRINS, PARTICULARLY αvβ3 INTEGRINS, METHOD FOR PREPARING SAME, INTERMEDIATES THEREFOR, USE OF SAID COMPOUNDS AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | HOECHST MARION ROUSSEL (FR) | 1997-09-25 | — | — | WO | disclosed |
| EP-0729933-A1 | Tricyclic derivatives, their preparation, their use in the preparation of optically active or racemic colchicine, thiocolchicine and analogues or derivatives, and intermediates | ROUSSEL-UCLAF (FR) | 1996-09-04 | — | — | EP | disclosed |