Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 7/20 | 0.48 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.48 |
| ▸ | CYP27A1 | Q02318 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7624883 | 0.83 | ESR1 (0.60) | MIFCYP26A1CYP27A1ABCB1MAPT | |
| SCHEMBL7628081 | 0.81 | ESR1 (0.63) | MIFCYP26A1CYP27A1ABCB1ALDH1A1 | |
| SCHEMBL20231362 | 0.80 | MAOB (0.50) | ALDH1A1SMN1; SMN2ESR1 | |
| SCHEMBL115122 | 0.80 | EBP (0.47) | MIFCYP26A1CYP27A1ALDH1A1CYP19A1 | |
| SCHEMBL10470879 | 0.79 | MIF (0.48) | MIFCYP26A1CYP27A1ABCB1ALDH1A1 | |
| SCHEMBL7633335 | 0.78 | MPO (0.51) | MIFCYP26A1ABCB1ALDH1A1CYP19A1 | |
| SCHEMBL23297257 | 0.76 | EBP (0.51) | MIFCYP26A1CYP27A1MAPTMAPK1 | |
| SCHEMBL113833 | 0.73 | EBP (0.73) | ESR1ESR2 | |
| SCHEMBL27320516 | 0.73 | TLR9 (0.42) | CYP26A1CYP27A1ALDH1A1MAPTALKBH3 | |
| SCHEMBL14033508 | 0.72 | MIF (0.81) | MIFCYP26A1CYP27A1ABCB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0955286-B1 | Dihydro- or tetrahydronaphthalene derivatives having (anti-)estrogen activity | AVENTIS PHARMA SA (FR) | 2002-08-07 | — | — | EP | disclosed |
| US-6005003-A | OSTEOPOROSIS TREATMENT | HOECHST MARION ROUSSEL (FR) | 1999-12-21 | — | — | US | disclosed |
| EP-0955286-A1 | Dihydro- or tetrahydronaphthalene derivatives having (anti-)estrogen activity | HOECHST MARION ROUSSEL (FR) | 1999-11-10 | — | — | EP | disclosed |