Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EBP | Q15125 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 3/20 | 0.43 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.41 |
| ▸ | CYP27A1 | Q02318 | 1/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23297257 | 0.83 | EBP (0.51) | EBPSIGMAR1ESR1CYP26A1CYP27A1 | |
| SCHEMBL7624883 | 0.83 | ESR1 (0.60) | EBPSIGMAR1ESR1CYP26A1CYP27A1 | |
| SCHEMBL3792224 | 0.81 | EBP (0.69) | EBPSIGMAR1ESR1ESR2MIF | |
| SCHEMBL113833 | 0.80 | EBP (0.73) | EBPSIGMAR1ESR1ESR2 | |
| SCHEMBL7633352 | 0.80 | MIF (0.48) | ESR1CYP26A1CYP27A1ALKBH3MAPT | |
| SCHEMBL3785482 | 0.78 | MPO (0.55) | EBPSIGMAR1MPOKDM4EMAPT | |
| SCHEMBL18845500 | 0.73 | ALKBH3 (0.40) | EBPSIGMAR1ESR1ALKBH3ESR2 | |
| SCHEMBL27320516 | 0.73 | TLR9 (0.42) | EBPSIGMAR1ESR1CYP26A1CYP27A1 | |
| SCHEMBL18850173 | 0.72 | ESR1 (0.52) | ESR1MAPTALDH1A1ESR2MIF | |
| SCHEMBL8468618 | 0.72 | EBP (0.41) | EBPSIGMAR1ESR1CYP26A1CYP27A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424839-A2 | A PROCESS FOR THE PREPARATION OF LASOFOXIFENE TARTRATE | Glenmark Generics Limited (IN) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010125578-A2 | A PROCESS FOR THE PREPARATION OF LASOFOXIFENE TARTRATE | GLENMARK GENERICS LIMITED (IN) | 2010-11-04 | — | — | WO | disclosed |