Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.51 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | MIF | P14174 | 6/20 | 0.43 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4802603 | 0.87 | MPO (0.60) | MPOELANEALDH1A1ABCB1CYP3A4 | |
| SCHEMBL14267917 | 0.83 | MPO (0.56) | MPOELANEABCB1CYP3A4MAPT | |
| SCHEMBL6858889 | 0.82 | MPO (0.57) | MPOELANEALDH1A1MIFCYP26A1 | |
| SCHEMBL21982918 | 0.80 | MAOB (0.51) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL3785482 | 0.79 | MPO (0.55) | MPOELANEALDH1A1ABCB1CYP3A4 | |
| SCHEMBL8310384 | 0.78 | BACE1 (0.49) | MPOELANEALDH1A1CYP3A4MAPT | |
| SCHEMBL7633352 | 0.78 | MIF (0.48) | ALDH1A1CYP2A6MIFCYP26A1ABCB1 | |
| SCHEMBL8309725 | 0.77 | ESR1 (0.52) | MPOELANEMIFCYP26A1CYP3A4 | |
| SCHEMBL7633012 | 0.76 | MPO (0.54) | MPOELANEALDH1A1ABCB1MAPT | |
| SCHEMBL23297253 | 0.75 | MPO (0.50) | MPOELANEMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0955286-B1 | Dihydro- or tetrahydronaphthalene derivatives having (anti-)estrogen activity | AVENTIS PHARMA SA (FR) | 2002-08-07 | — | — | EP | disclosed |
| US-6005003-A | OSTEOPOROSIS TREATMENT | HOECHST MARION ROUSSEL (FR) | 1999-12-21 | — | — | US | disclosed |
| EP-0955286-A1 | Dihydro- or tetrahydronaphthalene derivatives having (anti-)estrogen activity | HOECHST MARION ROUSSEL (FR) | 1999-11-10 | — | — | EP | disclosed |