Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | PDE6A | P16499 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | MC3R | P41968 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7632730 | 0.75 | ADRA1A (0.45) | TAAR1ADRA2AADRA2CADRA1AADRA2B | |
| Hydrochloric Acid SCHEMBL7630026 | 0.70 | ADRA1A (0.46) | ADRA1AADRA1DADRA1BKDM4E | |
| SCHEMBL7639413 | 0.70 | ADRA1A (0.46) | ADRA2AADRA2CADRA1AADRA2BADRA1D | |
| Fumaric Acid SCHEMBL7640065 | 0.69 | ADRA1A (0.41) | TAAR1ADRA2AADRA2CLMNACYP1A2 | |
| SCHEMBL7603676 | 0.69 | ADRA1A (0.62) | ADRA1AADRA1DADRA1B | |
| Hydrochloric Acid SCHEMBL7636606 | 0.68 | ADRA1A (0.60) | TAAR1ADRA2AADRA2CLMNACYP1A2 | |
| SCHEMBL7584002 | 0.67 | ADRA1A (0.45) | ADRA1AADRA1DADRA1BKDM4E | |
| SCHEMBL374886 | 0.65 | LMNA (0.60) | LMNACYP1A2TSHRKMT2A | |
| SCHEMBL27666923 | 0.65 | NISCH (0.57) | ADRA2AADRA2CADRA2BNISCH | |
| SCHEMBL24276925 | 0.65 | ADRA2C (0.36) | TAAR1ADRA2AADRA2CLMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1175406-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066563-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2000-11-09 | — | — | WO | disclosed |