Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.53 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8531872 | 0.88 | LMNA (0.51) | SMN1; SMN2LMNAHTTALDH1A1MAPT | |
| SCHEMBL6403050 | 0.88 | LMNA (0.51) | SMN1; SMN2LMNAHTTALDH1A1MAPT | |
| SCHEMBL6975810 | 0.82 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAHTTALDH1A1MAPT | |
| SCHEMBL2625198 | 0.82 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAHTTALDH1A1MAPT | |
| SCHEMBL13039632 | 0.81 | LMNA (0.56) | SMN1; SMN2LMNAHTTALDH1A1MAPT | |
| SCHEMBL11633473 | 0.78 | CES2 (0.46) | SMN1; SMN2LMNAALDH1A1MAPTCYP1A2 | |
| SCHEMBL8995348 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAHTTALDH1A1MAPT | |
| SCHEMBL11361358 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAHTTALDH1A1MAPT | |
| SCHEMBL17973359 | 0.78 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAHTTALDH1A1MAPT | |
| SCHEMBL1928398 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAHTTALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790974-B1 | SUBSTITUTED 4-BIARYLBUTYRIC OR 5-BIARYLPENTANOIC ACIDS AND DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITIORS | BAYER AG (US) | 2002-08-14 | — | — | EP | claimed |