Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 3/20 | 0.48 |
| ▸ | CES1 | P23141 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8531872 | 1.00 | LMNA (0.51) | LMNAALDH1A1SMN1; SMN2NPSR1TDP1 | |
| SCHEMBL13039632 | 0.93 | LMNA (0.56) | LMNAALDH1A1SMN1; SMN2NPSR1TDP1 | |
| SCHEMBL7635145 | 0.88 | SMN1; SMN2 (0.56) | LMNAALDH1A1SMN1; SMN2L3MBTL1CYP2C19 | |
| SCHEMBL12251084 | 0.86 | LMNA (0.55) | LMNAALDH1A1SMN1; SMN2NPSR1TDP1 | |
| SCHEMBL15834920 | 0.86 | LMNA (0.55) | LMNAALDH1A1SMN1; SMN2NPSR1TDP1 | |
| SCHEMBL11559815 | 0.83 | LMNA (0.50) | LMNAALDH1A1SMN1; SMN2NPSR1TDP1 | |
| SCHEMBL31513113 | 0.82 | CES1 (0.54) | LMNAALDH1A1SMN1; SMN2NPSR1TDP1 | |
| SCHEMBL22163778 | 0.82 | LMNA (0.54) | LMNAALDH1A1SMN1; SMN2NPSR1TDP1 | |
| SCHEMBL11204713 | 0.81 | ALDH1A1 (0.47) | LMNAALDH1A1SMN1; SMN2NPSR1TDP1 | |
| SCHEMBL9714996 | 0.81 | PGR (0.46) | LMNAALDH1A1SMN1; SMN2NPSR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050059658-A1 | Pyridazinone | BAYER AKTIENGESELLSCHAFT (DE) | 2005-03-17 | — | — | US | disclosed |
| EP-1404657-A1 | PYRIDAZINONE | Bayer HealthCare AG (DE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003002541-A1 | PYRIDAZINONE | BAYER HEALTHCARE AG (DE) | 2003-01-09 | — | — | WO | disclosed |
| EP-0885869-A1 | THERAPEUTIC AGENT FOR DIABETES | Japan Tobacco Inc. (JP) | 1998-12-23 | — | — | EP | disclosed |
| US-4230705-A | 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazines and their uses in treating anxiety | AMERICAN CYANAMID COMPANY (US) | 1980-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059658-A1 | Pyridazinone | TYMP, TPMT, PDXK | LMNA 3488/4885ALDH1A1 3281/4885SMN1; SMN2 4713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.