Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 14/20 | 0.34 |
| ▸ | HTR1D | P28221 | 14/20 | 0.34 |
| ▸ | HTR1B | P28222 | 14/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 14/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 14/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7635187 | 0.84 | GABRA1 (0.45) | GABRG2GABRB3GABRA3CYP2C9CYP2C19 | |
| SCHEMBL24632613 | 0.73 | HTR1A (0.32) | HTR1AHTR1DHTR1BSLC6A4KCNH2 | |
| SCHEMBL7636525 | 0.72 | GABRG2 (0.41) | GABRG2GABRB3GABRA3CYP2C19GABRA1 | |
| SCHEMBL427787 | 0.67 | HTR1A (0.46) | HTR1AHTR1DHTR1BSLC6A4KCNH2 | |
| SCHEMBL9669325 | 0.61 | GABRG2 (0.36) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL7392361 | 0.61 | GABRA1 (0.54) | GABRG2GABRB3GABRA3CYP2C19GABRA1 | |
| SCHEMBL8030562 | 0.60 | GABRG2 (0.39) | GABRG2GABRB3GABRA3CYP2C19GABRA1 | |
| SCHEMBL24632609 | 0.59 | GABRG2 (0.49) | HTR1AHTR1DHTR1BSLC6A4KCNH2 | |
| SCHEMBL8028116 | 0.59 | GABRG2 (0.32) | GABRG2GABRB3GABRA3 | |
| SCHEMBL11110301 | 0.58 | GABRA1 (0.48) | GABRG2GABRB3GABRA3CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625982-B1 | 4-OXO- AND 4H-IMIDAZO(5,1-C)(1,4)BENZOXAZINES USEFUL AS BENZODIAZEPINE RECEPTOR-BINDING AGENTS | UPJOHN CO (US) | 2002-06-12 | — | — | EP | claimed |