Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 8/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 8/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 8/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7635163 | 0.84 | HTR1A (0.34) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7635149 | 0.76 | GABRA1 (0.49) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8866535 | 0.73 | ALDH1A1 (0.48) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL11116926 | 0.65 | ALDH1A1 (0.61) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9229739 | 0.65 | ALDH1A1 (0.48) | ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL11133327 | 0.64 | GABRA1 (0.80) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL11885890 | 0.64 | ALDH1A1 (0.63) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9078086 | 0.63 | — | — | |
| SCHEMBL9075030 | 0.63 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9077500 | 0.63 | GABRA1 (0.46) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625982-B1 | 4-OXO- AND 4H-IMIDAZO(5,1-C)(1,4)BENZOXAZINES USEFUL AS BENZODIAZEPINE RECEPTOR-BINDING AGENTS | UPJOHN CO (US) | 2002-06-12 | — | — | EP | claimed |
| US-5610158-A | ANXIOLYTIC AGENTS, SEDATIVES | THE UPJOHN COMPANY (US) | 1997-03-11 | — | — | US | claimed |
| EP-0625982-B1 | 4-OXO- AND 4H-IMIDAZO(5,1-C)(1,4)BENZOXAZINES USEFUL AS BENZODIAZEPINE RECEPTOR-BINDING AGENTS | UPJOHN CO (US) | 2002-06-12 | — | — | EP | disclosed |
| US-5610158-A | ANXIOLYTIC AGENTS, SEDATIVES | THE UPJOHN COMPANY (US) | 1997-03-11 | — | — | US | disclosed |
| EP-0625982-A1 | 4-OXO- AND 4H-IMIDAZO(5,1-C)(1,4)BENZOXAZINES USEFUL AS BENZODIAZEPINE RECEPTOR-BINDING AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 1994-11-30 | — | — | EP | disclosed |
| WO-1993016082-A1 | 4-OXO- AND 4H-IMIDAZO(5,1-C)(1,4)BENZOXAZINES USEFUL AS BENZODIAZEPINE RECEPTOR-BINDING AGENTS | THE UPJOHN COMPANY (US) | 1993-08-19 | — | — | WO | disclosed |