Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16594362 | 0.89 | TSHR (0.56) | TSHRLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL3120643 | 0.87 | TSHR (0.50) | TSHRLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL5677947 | 0.87 | LMNA (0.62) | TSHRLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL903883 | 0.87 | TSHR (0.58) | TSHRLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL4169813 | 0.85 | TDP1 (0.52) | RAB9ANPC1L3MBTL1LTA4HBCHE | |
| SCHEMBL9478520 | 0.83 | KCNA3 (0.56) | TSHRMAOBLTA4HCHRNA7BCHE | |
| SCHEMBL10713484 | 0.82 | TSHR (0.54) | TSHRLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL4756260 | 0.82 | MAOB (0.70) | TSHRLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL6852321 | 0.81 | LMNA (0.64) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL20425463 | 0.81 | RAB9A (0.58) | LMNACYP1A2PTGS1SLC6A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479659-B2 | IMPROVED PROCESS AND NOVEL INTERMEDIATES TO ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION | 2002-11-12 | — | — | US | disclosed |
| US-6147232-A | Process of making 3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic acid derivatives | SMITHKLINE BEECHAM CORPORATION (US) | 2000-11-14 | — | — | US | disclosed |