SCHEMBL7638696

SCHEMBL7638696

O=C(c1cccnc1Cl)C(Br)c1cccnc1Cl

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.54
SMN1; SMN2 Q16637 2/20 0.54
POLB P06746 1/20 0.42
EGFR P00533 4/20 0.42
KMT2A Q03164 2/20 0.42
MEN1 O00255 1/20 0.42
NPC1 O15118 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
CYP1A2 P05177 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
CASP3 P42574 1/20 0.40
SENP8 Q96LD8 1/20 0.40
SENP7 Q9BQF6 1/20 0.40
SENP6 Q9GZR1 1/20 0.40
GFER P55789 1/20 0.40
TDP1 Q9NUW8 1/20 0.39
GAA P10253 1/20 0.39
ALDH1A1 P00352 1/20 0.39
HPGD P15428 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3635902 0.81 SMN1; SMN2 (0.50) LMNASMN1; SMN2POLBEGFRKMT2A
SCHEMBL11145921 0.76 SMN1; SMN2 (0.41) LMNASMN1; SMN2POLBKMT2ANPC1
SCHEMBL3639309 0.76 ALDH1A1 (0.43) LMNASMN1; SMN2POLBKMT2AMEN1
SCHEMBL13415863 0.76 LMNA (0.61) LMNASMN1; SMN2POLBEGFRKMT2A
SCHEMBL6713160 0.76 LMNA (0.61) LMNASMN1; SMN2POLBEGFRKMT2A
SCHEMBL31568932 0.76 LMNA (0.61) LMNASMN1; SMN2POLBEGFRKMT2A
SCHEMBL28244754 0.73 LMNA (0.68) LMNASMN1; SMN2POLBEGFRKMT2A
SCHEMBL950218 0.73 LMNA (0.73) LMNASMN1; SMN2POLBEGFRKMT2A
SCHEMBL218606 0.73 LMNA (0.61) LMNASMN1; SMN2POLBEGFRKMT2A
SCHEMBL105459 0.71 SMN1; SMN2 (0.70) LMNASMN1; SMN2POLBEGFRKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1001782-A4 5,6-HETEROARYL-DIPYRIDO 2,3-$i(b):3',2'-$i(f)]AZEPINES AND THEIR USE IN THE PREVENTION OR TREATMENT OF HIV INFECTION BOEHRINGER INGELHEIM PHARMA (US) 2002-01-30 EP disclosed
EP-1001782-A1 5,6-HETEROARYL-DIPYRIDO 2,3-$i(b):3',2'-$i(f)]AZEPINES AND THEIR USE IN THE PREVENTION OR TREATMENT OF HIV INFECTION BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) 2000-05-24 EP disclosed
US-5919779-A VIRICIDE BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 1999-07-06 US disclosed
WO-1999007379-A1 5,6-HETEROARYL-DIPYRIDO[2,3-b:3',2'-f]AZEPINES AND THEIR USE IN THE PREVENTION OR TREATMENT OF HIV INFECTION BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 1999-02-18 WO disclosed