Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 11/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 11/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14260229 | 0.84 | ADRB2 (0.39) | ADRB2ADRB1LMNAADRB3HTR1A | |
| SCHEMBL10150183 | 0.81 | ALDH1A1 (0.36) | ADRB2ADRB1LMNAADRB3HTR1A | |
| SCHEMBL13392151 | 0.80 | LMNA (0.47) | ADRB2ADRB1LMNAADRB3HTR1A | |
| SCHEMBL13410928 | 0.80 | CYP1A2 (0.49) | ADRB2ADRB1LMNAADRB3HTR1A | |
| SCHEMBL745791 | 0.80 | CYP1A2 (0.49) | ADRB2ADRB1LMNAADRB3HTR1A | |
| SCHEMBL14260234 | 0.80 | LMNA (0.34) | ADRB2ADRB1LMNAADRB3CYP2D6 | |
| SCHEMBL750165 | 0.79 | ALOX15 (0.48) | ADRB2ADRB1LMNAADRB3HTR1A | |
| SCHEMBL14046821 | 0.78 | ADRB2 (0.52) | ADRB2ADRB1 | |
| SCHEMBL3303039 | 0.75 | ADRB2 (0.51) | ADRB2ADRB1HTR1A | |
| SCHEMBL12310073 | 0.73 | LMNA (0.53) | ADRB2ADRB1LMNAADRB3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2431380-A2 | Macrocyclic antagonist of the motilin receptor for treatment of gastrointestinal dysmotility disorders | Tranzyme Pharma, Inc. (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2008033328-A2 | MACROCYCLIC ANTAGONISTS OF THE MOTILIN RECEPTOR FOR TREATMENT OF GASTROINTESTINAL DYSMOTILITY DISORDERS | TRANZYME PHARMA, INC. (US) | 2008-03-20 | — | — | WO | disclosed |