SCHEMBL7642933

SCHEMBL7642933

COC(=O)CCc1cc(-c2nc3cc(Cl)ccc3s2)c(O)c(C(C)(C)C)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AGPAT2 O15120 5/20 0.47
SENP7 Q9BQF6 2/20 0.47
CASP3 P42574 1/20 0.47
SENP8 Q96LD8 1/20 0.47
SENP6 Q9GZR1 1/20 0.47
NPC1 O15118 1/20 0.41
PKM P14618 1/20 0.41
HPGD P15428 1/20 0.41
NFKB1 P19838 1/20 0.41
RAB9A P51151 1/20 0.41
NFKB2 Q00653 1/20 0.41
RELA Q04206 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
GAA P10253 4/20 0.41
MGAM O43451 1/20 0.41
SI P14410 1/20 0.41
MGAM2 Q2M2H8 1/20 0.41
HDAC6 Q9UBN7 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7723145 0.87 MAPT (0.47) NPC1PKMHPGDNFKB1RAB9A
SCHEMBL6050509 0.86 SENP7 (0.44) AGPAT2SENP7CASP3SENP8SENP6
SCHEMBL6928491 0.83 ALDH1A1 (0.42) AGPAT2SENP7CASP3SENP8SENP6
SCHEMBL2177466 0.77 MGAM (0.51) AGPAT2SENP7CASP3SENP8SENP6
SCHEMBL2354486 0.77 MGAM (0.51) AGPAT2SENP7CASP3SENP8SENP6
SCHEMBL29946134 0.77 MGAM (0.51) AGPAT2SENP7CASP3SENP8SENP6
SCHEMBL30672844 0.77 SENP7 (0.41) AGPAT2SENP7CASP3SENP8SENP6
SCHEMBL29269889 0.77 SENP7 (0.41) AGPAT2SENP7CASP3SENP8SENP6
SCHEMBL991097 0.76 GAA (0.40) SMN1; SMN2GAAPTGS1EGFRKMT2A
SCHEMBL490767 0.74 GAA (0.67) NFKB1SMN1; SMN2GAACYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1242391-A1 STABILIZER MIXTURE Ciba SC Holding AG (CH) 2002-09-25 EP disclosed
WO-2001047900-A1 STABILIZER MIXTURE CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2001-07-05 WO disclosed
US-5610211-A 2,2,6,6-tetramethylpiperidine derivatives for use as stabilizing agents for organic materials CIBA-GEIGY CORPORATION (US) 1997-03-11 US disclosed