Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.34 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.34 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.34 |
| ▸ | GPR3 | P46089 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30955953 | 0.77 | GPR3 (0.33) | GPR3HTR2APOLBKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL27182290 | 0.77 | MAP2K7 (0.30) | — | |
| Ethane SCHEMBL8163438 | 0.76 | GPR3 (0.44) | GPR3HTR2APOLBACHECHRM2 | |
| Hydrochloric Acid SCHEMBL618216 | 0.75 | GPR3 (0.42) | GPR3HTR2APOLBACHECHRM2 | |
| Hydrochloric Acid SCHEMBL27182326 | 0.74 | BCHE (0.31) | ACHEBCHE | |
| Hydrochloric Acid SCHEMBL8599251 | 0.73 | GPR3 (0.41) | GPR3HTR2APOLBACHECHRM2 | |
| Hydrochloric Acid SCHEMBL8378993 | 0.73 | GPR3 (0.41) | GPR3HTR2APOLBACHECHRM2 | |
| Hydrochloric Acid SCHEMBL6693835 | 0.73 | CYP1A2 (0.33) | CYP1A2 | |
| Iodide SCHEMBL27182250 | 0.73 | MAP2K7 (0.30) | — | |
| Bromide SCHEMBL27203207 | 0.73 | MAP2K7 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0855413-B1 | Ethylene copolymer rubber composition | JSR CORP (JP) | 2002-01-02 | — | — | EP | disclosed |
| US-5914372-A | VULCANIZABLE RUBBER CONSISTS OF A COPOLYMER OF ETHYLENE-ALPHA-OLEFIN-NON-CONJUGATED DIENE, ATLEAST ONE VULCANIZING AGENT, AND A PEROXY CROOSLINKING AGENT | JSR CORPORATION (JP) | 1999-06-22 | — | — | US | disclosed |
| EP-0855413-A1 | Ethylene copolymer rubber composition | JAPAN SYNTHETIC RUBBER CO., LTD. (JP) | 1998-07-29 | — | — | EP | disclosed |