Known targets — ChEMBL curated mechanism
COXFA4COXFA4L2GPD2MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3
The experimentally established mechanism targets of Metformin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHF8 | Q9UPP1 | 8/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 8/20 | 0.39 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.35 |
| ▸ | KDM5C | P41229 | 5/20 | 0.35 |
| ▸ | KDM6B | O15054 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.35 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 7/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 7/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metformin SCHEMBL7647374 | 0.98 | PHF8 (0.41) | PHF8KDM2AKDM7AEGLN1KDM5C | |
| Metformin SCHEMBL1558869 | 0.98 | PHF8 (0.41) | PHF8KDM2AKDM7AEGLN1KDM5C | |
| Metformin SCHEMBL2815209 | 0.91 | SLC22A6 (0.41) | PHF8KDM2AKDM7ALMNA | |
| Adipic Acid SCHEMBL2812145 | 0.91 | LMNA (0.41) | LMNA | |
| Metformin SCHEMBL991940 | 0.89 | FFAR3 (0.46) | PHF8KDM2AKDM7AKDM4C | |
| Metformin SCHEMBL2231852 | 0.88 | LDHA (0.38) | — | |
| Metformin SCHEMBL991100 | 0.86 | FFAR3 (0.40) | — | |
| Metformin SCHEMBL2815239 | 0.86 | LDHA (0.36) | — | |
| Metformin SCHEMBL1557197 | 0.86 | GLRA1 (0.40) | — | |
| Succinic Acid SCHEMBL7644469 | 0.86 | PHF8 (0.41) | PHF8KDM2AKDM7AEGLN1KDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6660300-B1 | Antidiabetic metformin HCl salt; high water solubility and a limited window of absorption; hydrophilic and hydrophobic polymers | BRISTOL-MYERS SQUIBB CO. | 2003-12-09 | — | — | US | claimed |