Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.57 |
| ▸ | NAMPT | P43490 | 1/20 | 0.55 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | DPP4 | P27487 | 2/20 | 0.51 |
| ▸ | NOS3 | P29474 | 1/20 | 0.51 |
| ▸ | NOS1 | P29475 | 1/20 | 0.51 |
| ▸ | NOS2 | P35228 | 1/20 | 0.51 |
| ▸ | CCR3 | P51677 | 1/20 | 0.51 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19133513 | 0.95 | NAMPT (0.61) | SIGMAR1EPHX2NAMPTTMEM97MEN1 | |
| SCHEMBL5536198 | 0.90 | NAMPT (0.64) | SIGMAR1EPHX2NAMPTTMEM97MEN1 | |
| SCHEMBL5546309 | 0.88 | NAMPT (0.67) | SIGMAR1EPHX2NAMPTTMEM97MEN1 | |
| SCHEMBL20707157 | 0.88 | NAMPT (0.67) | SIGMAR1EPHX2NAMPTTMEM97MEN1 | |
| SCHEMBL5543873 | 0.88 | NAMPT (0.67) | SIGMAR1EPHX2NAMPTTMEM97MEN1 | |
| SCHEMBL5515823 | 0.88 | NAMPT (0.67) | SIGMAR1EPHX2NAMPTTMEM97MEN1 | |
| SCHEMBL6948202 | 0.86 | SIGMAR1 (0.57) | SIGMAR1EPHX2NAMPTTMEM97MEN1 | |
| SCHEMBL17623676 | 0.85 | SIGMAR1 (0.60) | SIGMAR1EPHX2NAMPTTMEM97MEN1 | |
| SCHEMBL6939009 | 0.84 | HDAC3 (0.58) | SIGMAR1EPHX2NAMPTTMEM97MEN1 | |
| SCHEMBL6358663 | 0.84 | MGLL (0.62) | SIGMAR1EPHX2NAMPTTMEM97MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3196194-B1 | PYRIMIDINE DERIVATIVES USEFUL AS SELECTIVE JAK3 AND/OR JAK1 INHIBITORS | SHENZHEN CHIPSCREEN BIOSCIENCES LTD (CN) | 2019-08-07 | — | — | EP | disclosed |
| US-10011571-B2 | Preparation method for aromatic heterocyclic compound used as selective JAK3 and/or JAK1 kinase inhibitor and application of aromatic heterocyclic compound | SHENZHEN CHIPSCREEN BIOSCIENCES, LTD. (CN) | 2018-07-03 | — | — | US | disclosed |
| US-20170253566-A1 | PREPARATION METHOD FOR AROMATIC HETEROCYCLIC COMPOUND USED AS SELECTIVE JAK3 AND/OR JAK1 KINASE INHIBITOR AND APPLICATION OF AROMATIC HETEROCYCLIC COMPOUND | SHENZHEN CHIPSCREEN BIOSCIENCES, LTD. (CN) | 2017-09-07 | — | — | US | disclosed |
| EP-3196194-A1 | PREPARATION METHOD FOR AROMATIC HETEROCYCLIC COMPOUND USED AS SELECTIVE JAK3 AND/OR JAK1 KINASE INHIBITOR AND APPLICATION OF AROMATIC HETEROCYCLIC COMPOUND | Shenzhen Chipscreen Biosciences, Ltd. (CN) | 2017-07-26 | — | — | EP | disclosed |
| US-6479515-B1 | FOR THE TREATMENT OF PAIN AND INFLAMMATION, AND ESPECIALLY IN THE TREATMENT OF ASTHMA, CEREBRAL TRAUMATIC SHOCK AND ALLERGIC RHINITIS | FOURNIER INDUSTRIE ET SANTE (FR) | 2002-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10011571-B2 | Preparation method for aromatic heterocyclic compound used as selective JAK3 and/or JAK1 kinase inhibitor and application of aromatic heterocyclic compound | JAK3, JAK1, JAK2 | SIGMAR1 3019/4885EPHX2 3017/4885NAMPT 2038/4885 |
| US-20170253566-A1 | PREPARATION METHOD FOR AROMATIC HETEROCYCLIC COMPOUND USED AS SELECTIVE JAK3 AND/OR JAK1 KINASE INHIBITOR AND APPLICATION OF AROMATIC HETEROCYCLIC COMPOUND | JAK3, JAK1, JAK2 | SIGMAR1 3019/4885EPHX2 3017/4885NAMPT 2038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.