Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.57 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NAMPT | P43490 | 1/20 | 0.54 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | DPP4 | P27487 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | NOS3 | P29474 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.50 |
| ▸ | NOS2 | P35228 | 1/20 | 0.50 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5536198 | 0.89 | NAMPT (0.64) | SIGMAR1MEN1KMT2ANAMPTTMEM97 | |
| SCHEMBL20707157 | 0.87 | NAMPT (0.67) | SIGMAR1MEN1KMT2ANAMPTTMEM97 | |
| SCHEMBL5546309 | 0.87 | NAMPT (0.67) | SIGMAR1MEN1KMT2ANAMPTTMEM97 | |
| SCHEMBL5543873 | 0.87 | NAMPT (0.67) | SIGMAR1MEN1KMT2ANAMPTTMEM97 | |
| SCHEMBL5515823 | 0.87 | NAMPT (0.67) | SIGMAR1MEN1KMT2ANAMPTTMEM97 | |
| SCHEMBL6358663 | 0.86 | MGLL (0.62) | SIGMAR1MEN1KMT2ANAMPTTMEM97 | |
| SCHEMBL7644972 | 0.86 | SIGMAR1 (0.59) | SIGMAR1MEN1KMT2ANAMPTTMEM97 | |
| SCHEMBL17623676 | 0.84 | SIGMAR1 (0.60) | SIGMAR1MEN1KMT2ANAMPTTMEM97 | |
| SCHEMBL22265515 | 0.83 | L3MBTL1 (0.68) | SIGMAR1MEN1KMT2ANAMPTTMEM97 | |
| SCHEMBL28929238 | 0.83 | L3MBTL1 (0.68) | SIGMAR1MEN1KMT2ANAMPTTMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944618-B1 | NOVEL N-BENZENESULPHONYL-L-PROLINE DERIVATIVES, METHOD FOR PREPARING AND THERAPEUTIC USE | FOURNIER IND & SANTE (FR) | 2003-09-24 | — | — | EP | disclosed |
| US-6063791-A | N-benzenesulfonyl-L-proline derivatives, method for preparing and therapeutic use | FOURNIER INDUSTRIE ET SANTE (FR) | 2000-05-16 | — | — | US | disclosed |
| EP-0944618-A1 | NOVEL N-BENZENESULPHONYL-L-PROLINE DERIVATIVES, METHOD FOR PREPARING AND THERAPEUTIC USE | FOURNIER INDUSTRIE ET SANTE (FR) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998024783-A1 | NOVEL N-BENZENESULPHONYL-L-PROLINE DERIVATIVES, METHOD FOR PREPARING AND THERAPEUTIC USE | FOURNIER INDUSTRIE ET SANTE (FR) | 1998-06-11 | — | — | WO | disclosed |