Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 14/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380603 | 0.85 | CPA3 (0.41) | KDM4EGAATSHR | |
| SCHEMBL7645872 | 0.84 | BCHE (0.36) | TBXAS1NAPRTKDM4EGAATSHR | |
| SCHEMBL2230081 | 0.78 | TBXAS1 (0.42) | TBXAS1NAPRT | |
| SCHEMBL7644687 | 0.75 | HDAC1 (0.38) | NAPRTKDM4EHDAC6TSHRFFAR1 | |
| SCHEMBL7644468 | 0.75 | SLC1A3 (0.33) | KDM4E | |
| SCHEMBL7650927 | 0.75 | TSHR (0.41) | TBXAS1KDM4EHTTGAATSHR | |
| SCHEMBL28817540 | 0.72 | HTT (0.38) | TBXAS1HTTHDAC6 | |
| SCHEMBL7648560 | 0.71 | POLB (0.38) | KDM4EGAATSHRFFAR1 | |
| SCHEMBL3380508 | 0.69 | CPA3 (0.46) | KDM4EHDAC6TSHRFFAR1 | |
| SCHEMBL3380552 | 0.68 | HDAC1 (0.49) | HDAC6FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002515040-A | — | — | 2002-05-21 | — | — | JP | claimed |
| EP-0954295-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-11-10 | — | — | EP | claimed |
| WO-1997048409-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | claimed |