Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.35 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7576593 | 0.91 | ALDH1A1 (0.42) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL9526882 | 0.88 | ALDH1A1 (0.44) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL7646373 | 0.86 | L3MBTL1 (0.54) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL7645808 | 0.85 | AR (0.40) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL7409021 | 0.84 | ALDH1A1 (0.39) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL7644788 | 0.84 | PDE5A (0.45) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL7650356 | 0.83 | ALDH1A1 (0.38) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL9525981 | 0.81 | KDM4E (0.48) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL9702581 | 0.81 | ALDH1A1 (0.44) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL7376004 | 0.80 | PDE5A (0.50) | ALDH1A1KDM4EGLAGAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0428268-A2 | Pharmaceutical phenylpyridone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-05-22 | — | — | EP | claimed |
| US-6479520-B1 | REGULATING APOPTOSIS IN HUMAN CELLS WITH COMPOUNDS SUCH AS: 3-CYANO-6-(2-METHOXY-4-METHYLTHIOIPHENYL)-2(1H)-PYRIDINONE | CELL PATHWAYS, INC. | 2002-11-12 | — | — | US | disclosed |
| US-6046216-A | USEFUL TO INHIBIT THE GROWTH OF NEOPLASTIC CELLS. | CELL PATHWAYS, INC. (US) | 2000-04-04 | — | — | US | disclosed |
| EP-0428268-A2 | Pharmaceutical phenylpyridone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-05-22 | — | — | EP | disclosed |