Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL122496 | 0.93 | KDM4E (0.38) | KDM4EALDH1A1SMN1; SMN2ALOX12GAA | |
| Ethylene Glycol SCHEMBL3422304 | 0.88 | KDM4E (0.35) | KDM4EALDH1A1ALOX12TSHR | |
| SCHEMBL26099241 | 0.84 | KDM4E (0.37) | KDM4EHPGDALDH1A1SMN1; SMN2HTT | |
| SCHEMBL29018280 | 0.77 | KDM4E (0.45) | KDM4EALDH1A1SMN1; SMN2ALOX12TP53 | |
| Succinamide SCHEMBL7647282 | 0.73 | TSHR (0.36) | HPGDALDH1A1SMN1; SMN2HTTGAA | |
| SCHEMBL13182184 | 0.72 | KDM4E (0.44) | KDM4EHPGDALDH1A1SMN1; SMN2HTT | |
| SCHEMBL15528690 | 0.72 | KDM4E (0.42) | KDM4EHPGDALDH1A1SMN1; SMN2HTT | |
| SCHEMBL27165394 | 0.71 | KDM4E (0.35) | KDM4EALDH1A1ALOX12 | |
| Succinamide SCHEMBL28207191 | 0.70 | TSHR (0.32) | TSHR | |
| SCHEMBL8380249 | 0.69 | KDM4E (0.37) | KDM4EALDH1A1ALOX12TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423748-B1 | CONTACT LENSES ANTISEPTIC | ALCON MANUFACTURING, LTD. | 2002-07-23 | — | — | US | disclosed |
| US-6316669-B1 | OPHTHALMOLOGY | ALCON MANUFACTURING, LTD. | 2001-11-13 | — | — | US | disclosed |
| EP-1140805-A1 | AMIDO POLYBIGUANIDES AND THE USE THEREOF AS ANTIMICROBIAL AGENTS | Alcon Laboratories, Inc. (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1140804-A1 | BIS-AMIDO POLYBIGUANIDES AND THE USE THEREOF TO DISINFECT CONTACT LENSES AND PRESERVE PHARMACEUTICAL COMPOSITIONS | Alcon Laboratories, Inc. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035862-A1 | AMIDO POLYBIGUANIDES AND THE USE THEREOF AS ANTIMICROBIAL AGENTS | ALCON LABORATORIES, INC. (US) | 2000-06-22 | — | — | WO | disclosed |
| WO-2000035861-A1 | BIS-AMIDO POLYBIGUANIDES AND THE USE THEREOF TO DISINFECT CONTACT LENSES AND PRESERVE PHARMACEUTICAL COMPOSITIONS | ALCON LABORATORIES, INC. (US) | 2000-06-22 | — | — | WO | disclosed |