SCHEMBL8380249

SCHEMBL8380249

NC(=O)NN1C(=O)CCC1=O

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.37
TSHR P16473 3/20 0.33
ALDH1A1 P00352 2/20 0.32
ALPL P05186 1/20 0.32
POLB P06746 1/20 0.32
ALPI P09923 1/20 0.32
MAPT P10636 1/20 0.32
ALPG P10696 1/20 0.32
PLCG1 P19174 1/20 0.32
RECQL P46063 1/20 0.32
CASP6 P55212 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
ALOX12 P18054 1/20 0.31
NFKB1 P19838 2/20 0.30
CYP1A2 P05177 1/20 0.30
MAOA P21397 1/20 0.30
MAOB P27338 1/20 0.30
THPO P40225 1/20 0.30
CA2 P00918 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8883410 0.83 KDM4E (0.38) KDM4EALDH1A1POLBCA2CA9
SCHEMBL10978412 0.81 KDM4E (0.38) KDM4ETSHRALDH1A1ALPLPOLB
SCHEMBL31299898 0.79 KDM4E (0.39) KDM4EALDH1A1ALPLPOLBALPI
SCHEMBL11527806 0.79 KDM4E (0.48) KDM4EALDH1A1ALPLPOLBALPI
SCHEMBL31123680 0.78 KDM4E (0.33) KDM4E
SCHEMBL1162244 0.77 KDM4E (0.38) KDM4EALDH1A1ALPLPOLBALPI
SCHEMBL16327606 0.75 L3MBTL1 (0.47) KDM4EALDH1A1ALPLPOLBALPI
SCHEMBL122496 0.74 KDM4E (0.38) KDM4ETSHRALDH1A1MAPTL3MBTL1
SCHEMBL15528690 0.73 KDM4E (0.42) KDM4ETSHRALDH1A1ALPLPOLB
SCHEMBL28376408 0.73 KDM4E (0.36) KDM4EALDH1A1ALPLPOLBALPI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107922974-A Coupling of carboxyl-functional hydrophilic microbeads 生命技术公司 2018-04-17 CN claimed
US-12360106-B2 Photochromic xanthene fluorophores and their utility in live-cell imaging beyond the diffraction limit HOWARD HUGHES MEDICAL INSTITUTE (US) 2025-07-15 US disclosed
US-20250012787-A1 Photochromic xanthene fluorophores and their utility in live-cell imaging beyond the diffraction limit HOWARD HUGHES MEDICAL INSTITUTE (US) 2025-01-09 US disclosed
CN-108350490-B Substrates and methods for sequencing 生命技术公司 2022-06-21 CN disclosed
US-20210318293-A1 Photochromic xanthene fluorophores and their utility in live-cell imaging beyond the diffraction limit HOWARD HUGHES MEDICAL INSTITUTE (US) 2021-10-14 US disclosed
CN-108064253-B Polymer matrices formed from carboxy-functional acrylamides 生命技术公司 2020-09-15 CN disclosed
CN-108350490-A Substrates and Methods for Sequencing 生命技术公司 2018-07-31 CN disclosed
CN-108064253-A Polymer matrices formed from carboxy-functional acrylamides 生命技术公司 2018-05-22 CN disclosed
CN-107922974-A Coupling of carboxyl-functional hydrophilic microbeads 生命技术公司 2018-04-17 CN disclosed
EP-0904361-A1 IMMOBILIZED ALLIINASE AND CONTINUOUS PRODUCTION OF ALLICIN YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD. (IL) 1999-03-31 EP disclosed
EP-0882034-A1 SIALYL LEWIS X MIMETICS CONTAINING PHENYL BACKBONES GLYCOMED INCORPORATED (US) 1998-12-09 EP disclosed
EP-0830421-A1 MODIFIED AMINO CROSSLINKING AGENTS CYTEC TECHNOLOGY CORP. (US) 1998-03-25 EP disclosed
WO-1997039115-A1 IMMOBILIZED ALLIINASE AND CONTINUOUS PRODUCTION OF ALLICIN YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 1997-10-23 WO disclosed
US-5665852-A USEFUL IN POWDER COATING COMPOSITIONS CYTEC TECHNOLOGY CORP. (US) 1997-09-09 US disclosed
WO-1997030984-A1 SIALYL LEWISX MIMETICS CONTAINING PHENYL BACKBONES GLYCOMED INCORPORATED (US) 1997-08-28 WO disclosed
WO-1996040825-A1 MODIFIED AMINO CROSSLINKING AGENTS CYTEC TECHNOLOGY CORP. (US) 1996-12-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12360106-B2 Photochromic xanthene fluorophores and their utility in live-cell imaging beyond the diffraction limit XPA, KIF20A, KIF20B KDM4E 2253/4885TSHR 4213/4885ALDH1A1 3894/4885
US-20250012787-A1 Photochromic xanthene fluorophores and their utility in live-cell imaging beyond the diffraction limit XPA, KIF20A, KIF20B KDM4E 2337/4885TSHR 4230/4885ALDH1A1 3914/4885
US-20210318293-A1 Photochromic xanthene fluorophores and their utility in live-cell imaging beyond the diffraction limit XPA, KIF20A, KIF20B KDM4E 2253/4885TSHR 4213/4885ALDH1A1 3894/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.