Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | ALPI | P09923 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALPG | P10696 | 1/20 | 0.31 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL671509 | 0.81 | KDM4E (0.48) | KDM4EALDH1A1HPGDSMN1; SMN2GAA | |
| SCHEMBL19959701 | 0.81 | NFKB1 (0.40) | KDM4EALDH1A1SMN1; SMN2POLBRECQL | |
| SCHEMBL4132084 | 0.80 | KDM4E (0.36) | KDM4E | |
| SCHEMBL16327606 | 0.78 | L3MBTL1 (0.47) | KDM4EALDH1A1POLBGLAPKM | |
| SCHEMBL11527806 | 0.77 | KDM4E (0.48) | KDM4EALDH1A1POLBALPLALPI | |
| SCHEMBL31299898 | 0.77 | KDM4E (0.39) | KDM4EALDH1A1POLBALPLALPI | |
| SCHEMBL9390898 | 0.76 | KDM4E (0.37) | KDM4EGLATSHR | |
| SCHEMBL1162244 | 0.75 | KDM4E (0.38) | KDM4EALDH1A1SMN1; SMN2POLBALPL | |
| SCHEMBL31160375 | 0.74 | NFKB1 (0.38) | KDM4EALDH1A1HPGDSMN1; SMN2GLA | |
| SCHEMBL8380249 | 0.73 | KDM4E (0.37) | KDM4EALDH1A1POLBALPLALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649129-A1 | NOVEL HDAC6 INHIBITORS, WITH IMPROVED SOLUBILITY AND THEIR USES | Universität Regensburg (DE) | 2020-05-13 | — | — | EP | disclosed |
| WO-2019007836-A1 | NOVEL HDAC6 INHIBITORS, WITH IMPROVED SOLUBILITY AND THEIR USES | UNIVERSITÄT REGENSBURG (DE) | 2019-01-10 | — | — | WO | disclosed |
| EP-3390382-A1 | SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS | Ardelyx, Inc. (US) | 2018-10-24 | — | — | EP | disclosed |
| CN-108403698-A | Method and composition for treating bacterium infection | 密歇根大学董事会 | 2018-08-17 | — | — | CN | disclosed |
| WO-2017106818-A1 | SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS | ARDELYX, INC. (US) | 2017-06-22 | — | — | WO | disclosed |
| EP-2844258-A2 | METHODS AND COMPOSITIONS FOR TREATING BACTERIAL INFECTION | The Regents Of The University Of Michigan (US) | 2015-03-11 | — | — | EP | disclosed |
| WO-2013166282-A2 | METHODS AND COMPOSITIONS FOR TREATING BACTERIAL INFECTION | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-11-07 | — | — | WO | disclosed |