Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | CES2 | O00748 | 3/20 | 0.62 |
| ▸ | CES1 | P23141 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | ATM | Q13315 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.54 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4838009 | 0.79 | CES2 (0.71) | ALDH1A1CES2CES1LMNASMN1; SMN2 | |
| SCHEMBL9302245 | 0.78 | MAPT (0.54) | ALDH1A1LMNASMN1; SMN2TDP1KMT2A | |
| SCHEMBL167254 | 0.77 | CES2 (1.00) | ALDH1A1CES2CES1LMNASMN1; SMN2 | |
| SCHEMBL52200 | 0.77 | ALDH1A1 (1.00) | ALDH1A1CES2CES1LMNASMN1; SMN2 | |
| SCHEMBL822185 | 0.77 | ALDH1A1 (1.00) | ALDH1A1CES2CES1LMNASMN1; SMN2 | |
| SCHEMBL12362778 | 0.76 | ALDH1A1 (0.84) | ALDH1A1CES2CES1LMNASMN1; SMN2 | |
| SCHEMBL1775710 | 0.76 | ALDH1A1 (0.58) | ALDH1A1CES2CES1LMNASMN1; SMN2 | |
| SCHEMBL6113243 | 0.74 | ALDH1A1 (0.65) | ALDH1A1CES2CES1LMNASMN1; SMN2 | |
| SCHEMBL213538 | 0.74 | LMNA (0.60) | ALDH1A1CES2LMNAHTTTDP1 | |
| 4-Methylbenzoic Acid SCHEMBL11366477 | 0.74 | ALDH1A1 (1.00) | ALDH1A1CES2CES1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1983 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117298108-A | Androgen receptor and glucocorticoid receptor dual-target inhibitor and application thereof | 浙江师范大学 | 2023-12-29 | — | — | CN | claimed |
| US-20220213030-A1 | AMINOGUANIDINE HYDRAZONES AS RETROMER STABILIZERS USEFUL FOR TREATING NEUROLOGICAL DISEASES | OSPEDALE SAN RAFFAELE SRL (IT) | 2022-07-07 | — | — | US | claimed |
| CN-114341103-A | Aminoguanidinohydrazones as reverse transporter stabilizers useful for the treatment of neurological disorders | 圣拉斐尔医院有限公司 | 2022-04-12 | — | — | CN | claimed |
| EP-3947344-A1 | AMINOGUANIDINE HYDRAZONES AS RETROMER STABILIZERS USEFUL FOR TREATING NEUROLOGICAL DISEASES | Ospedale San Raffaele Srl (IT) | 2022-02-09 | — | — | EP | claimed |
| WO-2020201326-A1 | AMINOGUANIDINE HYDRAZONES AS RETROMER STABILIZERS USEFUL FOR TREATING NEUROLOGICAL DISEASES | OSPEDALE SAN RAFFAELE SRL (IT) | 2020-10-08 | — | — | WO | claimed |
| EP-1912988-B1 | 7-SUBSTITUTED AZA-INDAZOLES, COMPOSITIONS CONTAINING SAME, PRODUCTION METHOD AND USE THEREOF | AVENTIS PHARMA SA (FR) | 2014-04-16 | — | — | EP | claimed |
| US-8058290-B2 | E.g., 1-[4-(3-amino-1H-pyrazolo[3,4-b]pyridin-6-yl)phenyl]-3-(2-fluoro-5-trifluoromethylphenyl)urea; and N-(6-{4-[3-(2-fluoro-5-trifluoromethylphenyl)ureido]-phenyl}-1H-pyrazolo[3,4-b]pyridin-3-yl))thiophene-3-carboxamide; kinase inhibitors, anticancer agents | AVENTIS PHARMA S.A. (FR) | 2011-11-15 | — | — | US | claimed |
| US-20080182844-A1 | 7-Substituted Aza-Indazoles, Compositions Containing Same, Production Method and Use Thereof | AVENTIS PHARMA S.A. (FR) | 2008-07-31 | — | — | US | claimed |
| EP-1912988-A1 | 7-SUBSTITUTED AZA-INDAZOLES, COMPOSITIONS CONTAINING SAME, PRODUCTION METHOD AND USE THEREOF | Aventis Pharma S.A. (FR) | 2008-04-23 | — | — | EP | claimed |
| WO-2007017577-A1 | 7-SUBSTITUTED AZA-INDAZOLES, COMPOSITIONS CONTAINING SAME, PRODUCTION METHOD AND USE THEREOF | AVENTIS PHARMA S.A. (FR) | 2007-02-15 | — | — | WO | claimed |
| EP-0446748-A2 | Use of perylenedyes for the preparation of write, print or copying materials | RIEDEL-DE HAEN AKTIENGESELLSCHAFT (DE) | 1991-09-18 | — | — | EP | claimed |
| US-4942232-A | FOR PRINTING AND DYEING CELLULOSE FIBERS | BASF AKTIENGESELLSCHAFT (DE) | 1990-07-17 | — | — | US | claimed |
| US-4921887-A | ANTIALLERGENS | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1990-05-01 | — | — | US | claimed |
| US-4751288-A | COLORFASTNESS | BASF AKTIENGESELLSCHAFT (DE) | 1988-06-14 | — | — | US | claimed |
| US-4643849-A | ANTIULCER, ANTISECRETORY AGENTS | TOYAMA CHEMICAL CO., LTD. (JP) | 1987-02-17 | — | — | US | claimed |
| US-4604460-A | ANTIBIOTICS, BACTERICIDES | SHIONOGI & CO., LTD. (JP) | 1986-08-05 | — | — | US | claimed |
| US-4443598-A | ANTIBIOTICS AND INTERMEDIATES | SHIONOGI & CO., LTD. (JP) | 1984-04-17 | — | — | US | claimed |
| US-4308380-A | 2-Lower alkyl-2 or 3-cephem-4-carboxylic acid derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-12-29 | — | — | US | claimed |
| US-4122089-A | Aminothiofluoran compounds, process for the production thereof, and recording elements containing the same | SANKIO CHEMICAL CO., LTD. (JP) | 1978-10-24 | — | — | US | claimed |
| US-3987026-A | POLYESTERS | CIBA-GEIGY CORPORATION (US) | 1976-10-19 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220213030-A1 | AMINOGUANIDINE HYDRAZONES AS RETROMER STABILIZERS USEFUL FOR TREATING NEUROLOGICAL DISEASES | PARK7, HTT, HRH1 | ALDH1A1 188/4885CES2 3439/4885CES1 4027/4885 |
| US-20080182844-A1 | 7-Substituted Aza-Indazoles, Compositions Containing Same, Production Method and Use Thereof | PRMT7, PRKACA, PRKX | ALDH1A1 2144/4885CES2 2267/4885CES1 3077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.