Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | PPARD | Q03181 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | CYSLTR2 | Q9NS75 | 7/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9377031 | 0.89 | MAOB (0.40) | PPARGPPARDPPARALMNACYP1A2 | |
| SCHEMBL28743467 | 0.87 | PPARG (0.41) | PPARGPPARALMNACYSLTR2CYSLTR1 | |
| Bromide SCHEMBL9383528 | 0.80 | CYSLTR2 (0.41) | PPARGPPARDPPARALMNACYP1A2 | |
| SCHEMBL11022202 | 0.79 | POLB (0.46) | PPARGPPARDPPARALMNACYP1A2 | |
| SCHEMBL11020870 | 0.79 | POLB (0.46) | PPARGPPARDPPARALMNACYP1A2 | |
| SCHEMBL9376210 | 0.77 | PTPN1 (0.50) | LMNAMAPTPRKCIKMT2A | |
| SCHEMBL25329716 | 0.75 | LTA4H (0.46) | LMNACYP2C9KMT2AL3MBTL1CA9 | |
| SCHEMBL1415014 | 0.73 | MAOB (0.58) | PPARDMAOBKMT2A | |
| SCHEMBL11558997 | 0.73 | ALDH1A1 (0.45) | PPARGPPARALMNAMAPTGRM2 | |
| SCHEMBL12428822 | 0.73 | MAOB (0.44) | PPARGPPARDPPARALMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479671-B1 | Process for producing optically active chromene derivative | SHIONOGI & CO., LTD. (JP) | 2002-11-12 | — | — | US | disclosed |
| US-6218427-B1 | AS ENDOTHELIN RECEPTOR ANTAGONIST | SHIONOGI & CO., LTD. (JP) | 2001-04-17 | — | — | US | disclosed |
| EP-1057824-A1 | PROCESS FOR PRODUCING OPTICALLY ACTIVE CHROMENE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |
| EP-0924207-A1 | CHROMENE-3-CARBOXYLATE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 1999-06-23 | — | — | EP | disclosed |