Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 3/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604844 | 0.93 | POLB (0.47) | POLBALDH1A1MEN1KMT2AGAA | |
| SCHEMBL6601766 | 0.89 | POLB (0.43) | POLBALDH1A1MEN1KMT2AGAA | |
| SCHEMBL6602179 | 0.87 | PDE4D (0.45) | POLBALDH1A1MEN1KMT2A | |
| SCHEMBL6604041 | 0.86 | POLB (0.43) | POLBALDH1A1MEN1KMT2AGAA | |
| SCHEMBL6605449 | 0.85 | ALDH1A1 (0.48) | POLBALDH1A1GAAMAPTMAOB | |
| SCHEMBL6600745 | 0.85 | MAOB (0.48) | POLBALDH1A1GAAMAPTMAOB | |
| SCHEMBL6600682 | 0.85 | RAB9A (0.46) | POLBALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL6605509 | 0.84 | ABL1 (0.50) | POLBALDH1A1MEN1KMT2AMAOB | |
| SCHEMBL7645940 | 0.84 | ALDH1A1 (0.46) | POLBALDH1A1GAAMAOBPGR | |
| SCHEMBL6603998 | 0.83 | MAPT (0.51) | POLBALDH1A1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479494-B1 | THEY INHIBIT SELECTIVELY PHOSPHODIESTERASE IV, WHICH CAUSES AN INCREASE OF THE INTRACELLULAR CAMP LEVEL AS CAMP INHIBITS BONE DECREASING CELLS AND STIMULATES BONE INCREASING CELLS FOR TREATMENT OF OSTEOPOROSIS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-11-12 | — | — | US | disclosed |
| EP-1143944-A3 | USE OF ARYLALKANOYLPYRIDAZINES | MERCK PATENT GmbH (DE) | 2002-09-11 | — | — | EP | disclosed |
| EP-1143944-A2 | USE OF ARYLALKANOYLPYRIDAZINES | MERCK PATENT GmbH (DE) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000059484-A2 | USE OF ARYLALKANOYLPYRIDAZINES | MERCK PATENT GMBH (DE) | 2000-10-12 | — | — | WO | disclosed |
| US-6107295-A | Arylalkanoyl pyridazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-22 | — | — | US | disclosed |