Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
| ▸ | PADI1 | Q9ULC6 | 3/20 | 0.44 |
| ▸ | PADI3 | Q9ULW8 | 3/20 | 0.44 |
| ▸ | PADI4 | Q9UM07 | 3/20 | 0.44 |
| ▸ | PADI2 | Q9Y2J8 | 3/20 | 0.44 |
| ▸ | TGM2 | P21980 | 1/20 | 0.44 |
| ▸ | S100A4 | P26447 | 1/20 | 0.44 |
| ▸ | TOP2A | P11388 | 10/20 | 0.41 |
| ▸ | NSD2 | O96028 | 2/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29429719 | 0.70 | PTPN1 (0.68) | CDC25BPADI1PADI3PADI4PADI2 | |
| SCHEMBL228360 | 0.70 | PTPN1 (0.68) | CDC25BPADI1PADI3PADI4PADI2 | |
| SCHEMBL30002698 | 0.67 | S100A4 (0.39) | PADI1PADI3PADI4PADI2TGM2 | |
| SCHEMBL30003056 | 0.67 | PADI1 (0.39) | CDC25BPADI1PADI3PADI4PADI2 | |
| SCHEMBL4536691 | 0.66 | CDC25B (0.46) | CDC25BS100A4TOP2AKDM4EMEN1 | |
| SCHEMBL21448662 | 0.66 | S100A4 (0.54) | CDC25BPADI1PADI3PADI4PADI2 | |
| Sulfuric Acid SCHEMBL10338517 | 0.64 | HKDC1 (0.59) | CDC25BPADI1PADI3PADI4PADI2 | |
| SCHEMBL14593320 | 0.64 | CDC25B (0.70) | CDC25BS100A4TOP2ANSD2TDP2 | |
| SCHEMBL20711017 | 0.63 | PADI1 (0.47) | PADI1PADI3PADI4PADI2TGM2 | |
| SCHEMBL20711018 | 0.63 | S100A4 (0.47) | PADI1PADI3PADI4PADI2TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064396-A9 | NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING | GEORGETOWN UNIVERSITY (US) | 2012-07-05 | — | — | WO | disclosed |
| WO-2012064396-A2 | NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING | GEORGETOWN UNIVERSITY (US) | 2012-05-18 | — | — | WO | disclosed |