Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 7/20 | 0.47 |
| ▸ | PGR | P06401 | 3/20 | 0.43 |
| ▸ | RORA | P35398 | 2/20 | 0.43 |
| ▸ | RORC | P51449 | 2/20 | 0.43 |
| ▸ | RORB | Q92753 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7656674 | 0.96 | CNR2 (0.46) | CNR2PGRRORARORCRORB | |
| SCHEMBL7649598 | 0.83 | TSHR (0.55) | CNR2PGRRORARORCRORB | |
| SCHEMBL7649524 | 0.79 | TSHR (0.56) | CNR2PGRRORARORCRORB | |
| SCHEMBL5037066 | 0.77 | TNF (0.59) | CNR2PGRRORARORCRORB | |
| SCHEMBL31189225 | 0.76 | MPO (0.46) | CNR2PGRKDM4EMAPTALDH1A1 | |
| SCHEMBL22716908 | 0.76 | MPO (0.46) | CNR2PGRKDM4EMAPTALDH1A1 | |
| SCHEMBL29179745 | 0.75 | SLC6A4 (0.59) | PGRRORARORCRORBMAPT | |
| SCHEMBL4547798 | 0.74 | ERCC1 (0.44) | CNR2PGRKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4729188 | 0.74 | FABP4 (0.58) | — | |
| SCHEMBL7657372 | 0.74 | CNR2 (0.57) | CNR2KDM4EMAPTSMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |