Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.40 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | PTGIR | P43119 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 6/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5034614 | 1.00 | GAA (0.40) | GAAFABP4FABP5DRD2DRD4 | |
| SCHEMBL25230632 | 0.99 | GAA (0.41) | GAAFABP4FABP5DRD2DRD4 | |
| Iodide SCHEMBL565628 | 0.97 | GAA (0.40) | GAAFABP4FABP5DRD2DRD4 | |
| SCHEMBL14454734 | 0.97 | FABP4 (0.41) | GAAFABP4FABP5DRD2DRD4 | |
| Bromide SCHEMBL28672149 | 0.89 | DRD2 (0.42) | FABP4FABP5DRD2DRD4HDAC1 | |
| Bromide SCHEMBL5833274 | 0.89 | DRD2 (0.42) | FABP4FABP5DRD2DRD4HDAC1 | |
| SCHEMBL29521317 | 0.88 | DRD2 (0.43) | FABP4FABP5DRD2DRD4HDAC1 | |
| SCHEMBL5133368 | 0.88 | DRD2 (0.43) | FABP4FABP5DRD2DRD4HDAC1 | |
| SCHEMBL21768355 | 0.87 | DRD2 (0.39) | GAADRD2DRD4HDAC1HDAC6 | |
| Iodide SCHEMBL3454461 | 0.87 | DRD2 (0.42) | FABP4FABP5DRD2DRD4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358655-B1 | RESIN WITH CHELATION AGENT AND SPIROPYRAN COMPOUND PREPARED BY EMULSION AGGREGATION | XEROX CORPORATION | 2002-03-19 | — | — | US | disclosed |