Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 2/20 | 0.36 |
| ▸ | FABP3 | P05413 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28672149 | 1.00 | DRD2 (0.42) | DRD2DRD4HDAC1HDAC6MEN1 | |
| SCHEMBL29521317 | 0.99 | DRD2 (0.43) | DRD2DRD4HDAC1HDAC6MEN1 | |
| SCHEMBL5133368 | 0.99 | DRD2 (0.43) | DRD2DRD4HDAC1HDAC6MEN1 | |
| Iodide SCHEMBL3454461 | 0.97 | DRD2 (0.42) | DRD2DRD4HDAC1HDAC6MEN1 | |
| Bromide SCHEMBL7649880 | 0.89 | GAA (0.40) | DRD2DRD4HDAC1HDAC6MAPT | |
| Bromide SCHEMBL5034614 | 0.89 | GAA (0.40) | DRD2DRD4HDAC1HDAC6MAPT | |
| SCHEMBL14454734 | 0.89 | FABP4 (0.41) | DRD2DRD4HDAC1HDAC6MAPT | |
| SCHEMBL25230632 | 0.88 | GAA (0.41) | DRD2DRD4HDAC1HDAC6MAPT | |
| Iodide SCHEMBL565628 | 0.87 | GAA (0.40) | DRD2DRD4HDAC1HDAC6MAPT | |
| Quinoline SCHEMBL28853323 | 0.85 | L3MBTL1 (0.38) | DRD2DRD4HDAC1HDAC6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060199949-A1 | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods | CARNEGIE MELLON UNIVERSITY (US) | 2006-09-07 | — | — | US | disclosed |
| US-7008798-B2 | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods | CARNEGIE MELLON UNIVERSITY (US) | 2006-03-07 | — | — | US | disclosed |
| US-6989275-B2 | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods | CARNEGIE MELLON UNIVERSITY (US) | 2006-01-24 | — | — | US | disclosed |
| US-6956032-B1 | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods | CARNEGIE MELLON UNIVERSITY (US) | 2005-10-18 | — | — | US | disclosed |
| US-20020146736-A1 | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods | CARNEGIE MELLON UNIVERSITY | 2002-10-10 | — | — | US | disclosed |
| US-20020142340-A1 | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods | CARNEGIE MELLON UNIVERSITY | 2002-10-03 | — | — | US | disclosed |
| US-6225050-B1 | LABELING PROTEINS, CELLS, NUCLEIC ACIDS, SUGARS, CARBOHYDRATES, OR MIXTURES USING CYANINE DYE WHICH REACTS WITH AMINE, SULFHYDRYL, OR HYDROXY GROUPS OF COMPONENT | CARNEGIE MELLON UNIVERSITY | 2001-05-01 | — | — | US | disclosed |
| US-6048982-A | OXAZOLE, THIAZOLE OR IMIDAZOLE CYANINE DYES FOR LABELS | CARNEGIE MELLON UNIVERSITY (US) | 2000-04-11 | — | — | US | disclosed |
| US-5627027-A | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods | CARNEGIE MELLON UNIVERSITY (US) | 1997-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020142340-A1 | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods | SHBG, IK, PTMS | DRD2 1558/4885DRD4 875/4885HDAC1 4770/4885 |
| US-20060199949-A1 | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods | SHBG, IK, PTMS | DRD2 1558/4885DRD4 875/4885HDAC1 4770/4885 |
| US-20020146736-A1 | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods | SHBG, IK, PTMS | DRD2 1558/4885DRD4 875/4885HDAC1 4770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.