Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7650913 | 0.99 | ALDH1A1 (0.58) | ALDH1A1LMNATSHRCYP1A2CYP3A4 | |
| SCHEMBL7654548 | 0.88 | ALDH1A1 (0.71) | ALDH1A1LMNATSHRCYP1A2CYP3A4 | |
| SCHEMBL7649404 | 0.79 | HTR1E (0.70) | LMNATSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9912061 | 0.78 | ALDH1A1 (0.66) | ALDH1A1LMNATSHRCYP3A4CYP2C19 | |
| SCHEMBL14352723 | 0.78 | ALDH1A1 (0.66) | ALDH1A1LMNATSHRCYP3A4CYP2C19 | |
| SCHEMBL5079881 | 0.77 | ALDH1A1 (0.61) | ALDH1A1LMNATSHRCYP3A4CYP2C19 | |
| SCHEMBL4901879 | 0.75 | ALDH1A1 (0.58) | ALDH1A1LMNATSHRMEN1KMT2A | |
| SCHEMBL2846505 | 0.73 | GAA (0.68) | ALDH1A1LMNATSHRCYP1A2CYP3A4 | |
| SCHEMBL15354934 | 0.73 | CHRM2 (0.60) | ALDH1A1LMNATSHRCYP1A2CYP3A4 | |
| SCHEMBL19497139 | 0.73 | CHRM2 (0.60) | ALDH1A1LMNATSHRCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407120-B1 | ADMINISTERING PYRIDINYLACETAMIDE OR PHENYLACETAMIDE DERIVATIVE TO TREAT CARDIOVASCULAR, EATING, SEXUAL, BRAIN, NERVOUS SYSTEM, GASTROINTESTINAL, UROGENITAL, PSYCHOLOGICAL, AND RESPIRATORY SYSTEM DISORDERS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |