Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1E | P28566 | 3/20 | 0.70 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7654710 | 0.83 | SLC6A3 (0.57) | HTR1ES1PR3MEN1KMT2ALMNA | |
| SCHEMBL5114854 | 0.81 | HTR1E (0.69) | HTR1ES1PR3MEN1KMT2ALMNA | |
| SCHEMBL7649901 | 0.79 | ALDH1A1 (0.60) | MEN1KMT2ALMNAHTTRAB9A | |
| SCHEMBL7650913 | 0.77 | ALDH1A1 (0.58) | MEN1KMT2ALMNAHTTRAB9A | |
| SCHEMBL5049482 | 0.77 | CYP1A2 (0.63) | HTR1ES1PR3MEN1KMT2ALMNA | |
| SCHEMBL13923636 | 0.76 | HTR1E (0.74) | HTR1ES1PR3MEN1KMT2ALMNA | |
| SCHEMBL5049558 | 0.75 | HTR1E (0.64) | HTR1ES1PR3MEN1KMT2ALMNA | |
| SCHEMBL2844637 | 0.73 | HTR1E (0.69) | HTR1ES1PR3MEN1KMT2ALMNA | |
| SCHEMBL4866353 | 0.73 | CYP3A4 (0.63) | HTR1ES1PR3MEN1KMT2ALMNA | |
| SCHEMBL4278391 | 0.73 | CYP3A4 (0.60) | HTR1ES1PR3MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407120-B1 | ADMINISTERING PYRIDINYLACETAMIDE OR PHENYLACETAMIDE DERIVATIVE TO TREAT CARDIOVASCULAR, EATING, SEXUAL, BRAIN, NERVOUS SYSTEM, GASTROINTESTINAL, UROGENITAL, PSYCHOLOGICAL, AND RESPIRATORY SYSTEM DISORDERS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |