Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.97 |
| ▸ | DRD2 | P14416 | 9/20 | 0.97 |
| ▸ | HTR2A | P28223 | 9/20 | 0.97 |
| ▸ | DRD3 | P35462 | 9/20 | 0.97 |
| ▸ | HTR7 | P34969 | 7/20 | 0.97 |
| ▸ | HTR2B | P41595 | 6/20 | 0.97 |
| ▸ | HTR5A | P47898 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | HRH1 | P35367 | 4/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 3/20 | 0.52 |
| ▸ | DRD5 | P21918 | 3/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7647354 | 0.99 | HTR1A (1.00) | HTR1ADRD2HTR2ADRD3HTR7 | |
| Hydrochloric Acid SCHEMBL20359058 | 0.97 | HTR1A (1.00) | HTR1ADRD2HTR2ADRD3HTR7 | |
| SCHEMBL7647211 | 0.89 | DRD2 (0.82) | HTR1ADRD2HTR2ADRD3HTR7 | |
| SCHEMBL7645937 | 0.85 | HTR1A (0.75) | HTR1ADRD2HTR2ADRD3HTR7 | |
| SCHEMBL20364968 | 0.78 | HTR5A (1.00) | HTR1ADRD2HTR2ADRD3HTR7 | |
| Hydrochloric Acid SCHEMBL20359282 | 0.77 | HTR1A (1.00) | HTR1ADRD2HTR2ADRD3HTR7 | |
| SCHEMBL20364966 | 0.77 | HTR1A (0.97) | HTR1ADRD2HTR2ADRD3HTR7 | |
| Hydrochloric Acid SCHEMBL20359673 | 0.76 | HTR1A (1.00) | HTR1ADRD2HTR2ADRD3HTR7 | |
| SCHEMBL5448721 | 0.75 | HTR1A (0.62) | HTR1ADRD2HTR2ADRD3HTR7 | |
| SCHEMBL28992933 | 0.74 | HTR1A (0.60) | HTR1ADRD2HTR2ADRD3HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6486173-B2 | SEROTONIN-7 (5-HT7); TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS SUCH AS SLEEP DISORDERS, DEPRESSION AND SCHIZOPHRENIA; FOR EXAMPLE 1,3-DIHYDRO-2-((4-(4-FLUOROPHENYL)-4-OXOBUTYL))ISOINDOLE | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-11-26 | — | — | US | disclosed |
| US-20010041714-A1 | 5-HT7 receptor antagonists | CAIN GARY A (US) | 2001-11-15 | — | — | US | disclosed |
| US-6239143-B1 | TREATMENT CNS DISORDERS SUCH AS ANXIETY, DEPRESSION, SLEEP DISORDERS, AND SCHIZOPHRENIA. | DUPONT PHARMACEUTICALS COMPANY | 2001-05-29 | — | — | US | disclosed |
| WO-2000000472-A1 | 5-HT7 RECEPTOR ANTAGONISTS | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010041714-A1 | 5-HT7 receptor antagonists | HTR7, HTR5A, HTR1A | HTR1A 3/4885DRD2 100/4885HTR2A 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.