Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7650556 | 0.90 | PARP1 (0.43) | MAPTPARP1CA12CA9MEN1 | |
| SCHEMBL17433951 | 0.81 | KMT2A (0.60) | MAPTPOLBATMPARP1CA12 | |
| SCHEMBL7656522 | 0.80 | PARP1 (0.44) | MAPTPOLBPARP1KMT2ALMNA | |
| SCHEMBL7653099 | 0.80 | HDAC1 (0.43) | — | |
| SCHEMBL20567992 | 0.76 | MAPT (0.57) | MAPTPARP1CA12CA9MEN1 | |
| SCHEMBL7650175 | 0.76 | PARP1 (0.50) | MAPTPOLBPARP1LMNATDP1 | |
| SCHEMBL7301646 | 0.76 | PARP1 (0.59) | PARP1SIGMAR1 | |
| SCHEMBL4062222 | 0.74 | MAPT (0.50) | MAPTPOLBATMMEN1KMT2A | |
| SCHEMBL7648546 | 0.74 | ALDH1A1 (0.51) | MAPTPARP1MEN1KMT2ATDP1 | |
| SCHEMBL8806592 | 0.73 | PARP1 (0.55) | MAPTPARP1CA12CA9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |