Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.48 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8250528 | 0.93 | KDM4E (0.54) | KDM4EHSD17B10SMN1; SMN2TP53SIRT2 | |
| SCHEMBL8250523 | 0.82 | HSD17B10 (0.50) | KDM4EHSD17B10SMN1; SMN2TP53SIRT2 | |
| SCHEMBL7656174 | 0.78 | ALDH1A1 (0.53) | KDM4EHSD17B10SMN1; SMN2TP53SIRT2 | |
| SCHEMBL7662205 | 0.77 | SIRT2 (0.53) | KDM4EHSD17B10SMN1; SMN2TP53SIRT2 | |
| SCHEMBL7660819 | 0.77 | KDM4E (0.53) | KDM4EHSD17B10SMN1; SMN2TP53SIRT2 | |
| SCHEMBL8072656 | 0.76 | KDM4E (0.41) | KDM4EHSD17B10SMN1; SMN2TP53SIRT2 | |
| SCHEMBL7662862 | 0.76 | ALOX5 (0.40) | KDM4EHSD17B10SMN1; SMN2TP53SIRT2 | |
| SCHEMBL7655721 | 0.75 | ALOX5 (0.49) | KDM4EHSD17B10SMN1; SMN2TP53SIRT2 | |
| SCHEMBL7658336 | 0.74 | ALDH1A1 (0.42) | KDM4EHSD17B10SMN1; SMN2TP53SIRT2 | |
| SCHEMBL2952186 | 0.71 | PRKCI (0.52) | KDM4EHSD17B10SMN1; SMN2TP53SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6340704-B1 | TREATING NERVE DISEASE OR BONE/JOINT DISEASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-01-22 | — | — | US | disclosed |