Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.46 |
| ▸ | RORC | P51449 | 8/20 | 0.43 |
| ▸ | ITGAV | P06756 | 1/20 | 0.43 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 4/20 | 0.41 |
| ▸ | MMP9 | P14780 | 3/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7653489 | 0.90 | ITGB3 (0.46) | ITGB3ITGA2BRORCITGAVMLLT1 | |
| SCHEMBL7652565 | 0.84 | ITGB3 (0.52) | ITGB3ITGA2BRORCITGAV | |
| SCHEMBL7652999 | 0.83 | ITGB3 (0.52) | ITGB3ITGA2BITGAVALDH1A1MDM2 | |
| SCHEMBL7651238 | 0.81 | LMNA (0.41) | ITGB3ITGA2BRORCMLLT1ALDH1A1 | |
| SCHEMBL7649922 | 0.79 | ITGB3 (0.47) | ITGB3ITGA2BITGAVALDH1A1MDM2 | |
| SCHEMBL7654405 | 0.79 | ITGB3 (0.74) | ITGB3ITGA2BITGAV | |
| SCHEMBL7653549 | 0.79 | ITGB3 (0.47) | ITGB3ITGA2BITGAVALDH1A1MMP2 | |
| SCHEMBL7653506 | 0.79 | NPC1 (0.42) | ITGB3ITGA2BRORCMLLT1ALDH1A1 | |
| SCHEMBL7654222 | 0.78 | ITGB3 (0.72) | ITGB3ITGA2BRORCITGAV | |
| SCHEMBL7653684 | 0.77 | ITGB3 (0.70) | ITGB3ITGA2BITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | claimed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | claimed |
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |