Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TERT | O14746 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7648383 | 0.95 | L3MBTL1 (0.47) | CYP3A4CYP1A2CYP2D6TERTL3MBTL1 | |
| SCHEMBL7652443 | 0.90 | TERT (0.55) | TERTL3MBTL1HDAC1HDAC11HDAC8 | |
| SCHEMBL7653120 | 0.84 | HDAC1 (0.43) | CYP3A4CYP1A2CYP2D6L3MBTL1HDAC1 | |
| SCHEMBL4133285 | 0.81 | ALDH1A1 (0.58) | CYP1A2CYP2D6CA1CA2CA12 | |
| SCHEMBL7651347 | 0.80 | HDAC1 (0.46) | CYP3A4L3MBTL1HDAC1HDAC11HDAC8 | |
| SCHEMBL5306363 | 0.80 | CA1 (0.59) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL7653547 | 0.80 | SCN1A (0.51) | CYP1A2MEN1KMT2ACA1CA2 | |
| SCHEMBL5695284 | 0.79 | SOAT2 (0.60) | HDAC1HDAC11HDAC8HDAC6HDAC3 | |
| SCHEMBL9776434 | 0.79 | SOAT2 (0.60) | HDAC1HDAC11HDAC8HDAC6HDAC3 | |
| SCHEMBL1005094 | 0.79 | SOAT2 (0.60) | HDAC1HDAC11HDAC8HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002536440-A | — | — | 2002-10-29 | — | — | JP | claimed |
| EP-1155007-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. Searle LLC (US) | 2001-11-21 | — | — | EP | claimed |
| WO-2000047568-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. SEARLE LLC (US) | 2000-08-17 | — | — | WO | claimed |
| EP-1155007-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. Searle LLC (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047568-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. SEARLE LLC (US) | 2000-08-17 | — | — | WO | disclosed |